Please use this identifier to cite or link to this item:
https://doi.org/10.1038/s41467-017-00172-9
DC Field | Value | |
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dc.title | An intrinsic mechanism controls reactivation of neural stem cells by spindle matrix proteins | |
dc.contributor.author | Li S. | |
dc.contributor.author | Koe C.T. | |
dc.contributor.author | Tay S.T. | |
dc.contributor.author | Tan A.L.K. | |
dc.contributor.author | Zhang S. | |
dc.contributor.author | Zhang Y. | |
dc.contributor.author | Tan P. | |
dc.contributor.author | Sung W.-K. | |
dc.contributor.author | Wang H. | |
dc.date.accessioned | 2020-09-06T16:04:25Z | |
dc.date.available | 2020-09-06T16:04:25Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Li S., Koe C.T., Tay S.T., Tan A.L.K., Zhang S., Zhang Y., Tan P., Sung W.-K., Wang H. (2017). An intrinsic mechanism controls reactivation of neural stem cells by spindle matrix proteins. Nature Communications 8 (1) : 122. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-017-00172-9 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/174488 | |
dc.description.abstract | The switch between quiescence and proliferation is central for neurogenesis and its alteration is linked to neurodevelopmental disorders such as microcephaly. However, intrinsic mechanisms that reactivate Drosophila larval neural stem cells (NSCs) to exit from quiescence are not well established. Here we show that the spindle matrix complex containing Chromator (Chro) functions as a key intrinsic regulator of NSC reactivation downstream of extrinsic insulin/insulin-like growth factor signalling. Chro also prevents NSCs from ire-entering quiescence at later stages. NSC-specific in vivo profiling has dentified many downstream targets of Chro, including a temporal transcription factor Grainy head (Grh) and a neural stem cell quiescence-inducing factor Prospero (Pros). We show that spindle matrix proteins promote the expression of Grh and repress that of Pros in NSCs to govern their reactivation. Our data demonstrate that nuclear Chro critically regulates gene expression in NSCs at the transition from quiescence to proliferation. © 2017 The Author(s). | |
dc.publisher | Nature Publishing Group | |
dc.source | Unpaywall 20200831 | |
dc.subject | insulin | |
dc.subject | matrix protein | |
dc.subject | phosphatidylinositol 3 kinase | |
dc.subject | protein Chromator | |
dc.subject | somatomedin | |
dc.subject | transcription factor | |
dc.subject | transcription factor Grainy head | |
dc.subject | transcription factor Prospero | |
dc.subject | unclassified drug | |
dc.subject | chromator protein, Drosophila | |
dc.subject | DNA binding protein | |
dc.subject | Drosophila protein | |
dc.subject | EAST protein, Drosophila | |
dc.subject | grh protein, Drosophila | |
dc.subject | megator protein, Drosophila | |
dc.subject | nerve protein | |
dc.subject | nuclear matrix protein | |
dc.subject | nuclear protein | |
dc.subject | phosphoprotein | |
dc.subject | pros protein, Drosophila | |
dc.subject | transcription factor | |
dc.subject | biochemistry | |
dc.subject | biological development | |
dc.subject | cells and cell components | |
dc.subject | gene expression | |
dc.subject | growth | |
dc.subject | hormone | |
dc.subject | nervous system disorder | |
dc.subject | physiology | |
dc.subject | protein | |
dc.subject | reactivation | |
dc.subject | animal cell | |
dc.subject | animal tissue | |
dc.subject | Article | |
dc.subject | cell proliferation | |
dc.subject | controlled study | |
dc.subject | Drosophila | |
dc.subject | neural stem cell | |
dc.subject | nonhuman | |
dc.subject | protein function | |
dc.subject | signal transduction | |
dc.subject | animal | |
dc.subject | confocal microscopy | |
dc.subject | cytology | |
dc.subject | Drosophila melanogaster | |
dc.subject | gene expression profiling | |
dc.subject | genetics | |
dc.subject | larva | |
dc.subject | metabolism | |
dc.subject | neural stem cell | |
dc.subject | procedures | |
dc.subject | RNA interference | |
dc.subject | transgenic animal | |
dc.subject | Western blotting | |
dc.subject | Prospero | |
dc.subject | Animals | |
dc.subject | Animals, Genetically Modified | |
dc.subject | Blotting, Western | |
dc.subject | DNA-Binding Proteins | |
dc.subject | Drosophila melanogaster | |
dc.subject | Drosophila Proteins | |
dc.subject | Gene Expression Profiling | |
dc.subject | Larva | |
dc.subject | Microscopy, Confocal | |
dc.subject | Nerve Tissue Proteins | |
dc.subject | Neural Stem Cells | |
dc.subject | Nuclear Matrix-Associated Proteins | |
dc.subject | Nuclear Proteins | |
dc.subject | Phosphoproteins | |
dc.subject | RNA Interference | |
dc.subject | Transcription Factors | |
dc.type | Article | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.contributor.department | PHYSIOLOGY | |
dc.contributor.department | DEPARTMENT OF COMPUTER SCIENCE | |
dc.description.doi | 10.1038/s41467-017-00172-9 | |
dc.description.sourcetitle | Nature Communications | |
dc.description.volume | 8 | |
dc.description.issue | 1 | |
dc.description.page | 122 | |
Appears in Collections: | Elements Staff Publications |
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