Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep41338
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dc.titleSerum bilirubin levels and risk of type 2 diabetes: Results from two independent cohorts in middle-aged and elderly Chinese
dc.contributor.authorWang, J
dc.contributor.authorLi, Y
dc.contributor.authorHan, X
dc.contributor.authorHu, H
dc.contributor.authorWang, F
dc.contributor.authorLi, X
dc.contributor.authorYang, K
dc.contributor.authorYuan, J
dc.contributor.authorYao, P
dc.contributor.authorMiao, X
dc.contributor.authorWei, S
dc.contributor.authorWang, Y
dc.contributor.authorCheng, W
dc.contributor.authorLiang, Y
dc.contributor.authorZhang, X
dc.contributor.authorGuo, H
dc.contributor.authorYang, H
dc.contributor.authorYuan, J
dc.contributor.authorKoh, W.-P
dc.contributor.authorHu, F.B
dc.contributor.authorWu, T
dc.contributor.authorPan, A
dc.contributor.authorHe, M
dc.date.accessioned2020-09-04T03:42:56Z
dc.date.available2020-09-04T03:42:56Z
dc.date.issued2017
dc.identifier.citationWang, J, Li, Y, Han, X, Hu, H, Wang, F, Li, X, Yang, K, Yuan, J, Yao, P, Miao, X, Wei, S, Wang, Y, Cheng, W, Liang, Y, Zhang, X, Guo, H, Yang, H, Yuan, J, Koh, W.-P, Hu, F.B, Wu, T, Pan, A, He, M (2017). Serum bilirubin levels and risk of type 2 diabetes: Results from two independent cohorts in middle-aged and elderly Chinese. Scientific Reports 7 : 41338. ScholarBank@NUS Repository. https://doi.org/10.1038/srep41338
dc.identifier.issn2045-2322
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/174434
dc.description.abstractSerum bilirubin is a potent endogenous antioxidant and has been identified as cardiovascular risk in cohort studies, while the relation to type 2 diabetes (T2D) in the elderly remains unclear. We investigated both cross-sectional and prospective associations between serum bilirubin levels and T2D risk in the Dongfeng-Tongji (DFTJ) cohort, and replicated the prospective findings in a nested case-control study (509 cases and 509 controls) within the Singapore Chinese Health Study (SCHS). In the cross-Sectional analysis of DFTJ cohort (15,575 participants with 2,532 diabetes cases), serum bilirubin levels (total, direct and indirect) increased in new on-set diabetes and decreased with the diabetic duration. In the longitudinal analysis of DFTJ cohort (772 incident diabetes cases during 4.5 years of follow-Up among 12,530 diabetes-Free participants at baseline), positive association was found between direct bilirubin and T2D risk comparing extreme quartiles, similar results were observed in the nested case-control study within SCHS. Total and indirect bilirubin levels were not significantly associated with T2D in either cohort. In conclusion, our findings do not support the protective association between serum bilirubin levels and incident T2D in the middle-Aged and elderly adults; instead, direct bilirubin levels were associated with increased risk of T2D.
dc.publisherNature Publishing Group
dc.sourceUnpaywall 20200831
dc.subjectbilirubin
dc.subjectadult
dc.subjectaged
dc.subjectAsian continental ancestry group
dc.subjectblood
dc.subjectChina
dc.subjectcohort analysis
dc.subjectfemale
dc.subjecthuman
dc.subjectmale
dc.subjectmiddle aged
dc.subjectnon insulin dependent diabetes mellitus
dc.subjectrisk factor
dc.subjectAdult
dc.subjectAged
dc.subjectAsian Continental Ancestry Group
dc.subjectBilirubin
dc.subjectChina
dc.subjectCohort Studies
dc.subjectDiabetes Mellitus, Type 2
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectRisk Factors
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.contributor.departmentLIFE SCIENCES INSTITUTE
dc.description.doi10.1038/srep41338
dc.description.sourcetitleScientific Reports
dc.description.volume7
dc.description.page41338
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