Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep41338
Title: Serum bilirubin levels and risk of type 2 diabetes: Results from two independent cohorts in middle-aged and elderly Chinese
Authors: Wang, J
Li, Y
Han, X
Hu, H
Wang, F
Li, X
Yang, K
Yuan, J
Yao, P
Miao, X
Wei, S
Wang, Y
Cheng, W
Liang, Y
Zhang, X
Guo, H
Yang, H
Yuan, J
Koh, W.-P 
Hu, F.B
Wu, T
Pan, A 
He, M
Keywords: bilirubin
adult
aged
Asian continental ancestry group
blood
China
cohort analysis
female
human
male
middle aged
non insulin dependent diabetes mellitus
risk factor
Adult
Aged
Asian Continental Ancestry Group
Bilirubin
China
Cohort Studies
Diabetes Mellitus, Type 2
Female
Humans
Male
Middle Aged
Risk Factors
Issue Date: 2017
Publisher: Nature Publishing Group
Citation: Wang, J, Li, Y, Han, X, Hu, H, Wang, F, Li, X, Yang, K, Yuan, J, Yao, P, Miao, X, Wei, S, Wang, Y, Cheng, W, Liang, Y, Zhang, X, Guo, H, Yang, H, Yuan, J, Koh, W.-P, Hu, F.B, Wu, T, Pan, A, He, M (2017). Serum bilirubin levels and risk of type 2 diabetes: Results from two independent cohorts in middle-aged and elderly Chinese. Scientific Reports 7 : 41338. ScholarBank@NUS Repository. https://doi.org/10.1038/srep41338
Abstract: Serum bilirubin is a potent endogenous antioxidant and has been identified as cardiovascular risk in cohort studies, while the relation to type 2 diabetes (T2D) in the elderly remains unclear. We investigated both cross-sectional and prospective associations between serum bilirubin levels and T2D risk in the Dongfeng-Tongji (DFTJ) cohort, and replicated the prospective findings in a nested case-control study (509 cases and 509 controls) within the Singapore Chinese Health Study (SCHS). In the cross-Sectional analysis of DFTJ cohort (15,575 participants with 2,532 diabetes cases), serum bilirubin levels (total, direct and indirect) increased in new on-set diabetes and decreased with the diabetic duration. In the longitudinal analysis of DFTJ cohort (772 incident diabetes cases during 4.5 years of follow-Up among 12,530 diabetes-Free participants at baseline), positive association was found between direct bilirubin and T2D risk comparing extreme quartiles, similar results were observed in the nested case-control study within SCHS. Total and indirect bilirubin levels were not significantly associated with T2D in either cohort. In conclusion, our findings do not support the protective association between serum bilirubin levels and incident T2D in the middle-Aged and elderly adults; instead, direct bilirubin levels were associated with increased risk of T2D.
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/174434
ISSN: 2045-2322
DOI: 10.1038/srep41338
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