Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41467-017-00196-1
Title: Molecular characterization of breast cancer CTCs associated with brain metastasis
Authors: Boral, D
Vishnoi, M
Liu, H.N
Yin, W
Sprouse, M.L
Scamardo, A
Hong, D.S
Tan, T.Z 
Thiery, J.P 
Chang, J.C
Marchetti, D
Keywords: biological marker
CD86 antigen
chemokine receptor CXCR4
cytokeratin
epidermal growth factor receptor 2
epithelial cell adhesion molecule
estrogen receptor
Hermes antigen
interleukin 1beta
interleukin 8
Ki 67 antigen
messenger RNA
transcriptome
epithelial cell adhesion molecule
transcriptome
tumor marker
biomarker
brain
cancer
cells and cell components
gene
gene expression
mutation
tumor
advanced cancer
apoptosis
Article
brain metastasis
breast cancer
CD4+ T lymphocyte
CD8+ T lymphocyte
cell isolation
cell population
cell proliferation
cell subpopulation
cell surface
cell survival
chemotaxis
circulating tumor cell
human
human cell
micrometastasis
protein expression
transcriptomics
whole genome sequencing
blood
brain tumor
breast tumor
DNA sequence
early cancer diagnosis
female
gene expression regulation
genetics
metabolism
nucleotide sequence
pathology
procedures
secondary
tumor embolism
Base Sequence
Biomarkers, Tumor
Brain Neoplasms
Breast Neoplasms
Early Detection of Cancer
Epithelial Cell Adhesion Molecule
Female
Gene Expression Regulation, Neoplastic
Humans
Neoplastic Cells, Circulating
Sequence Analysis, DNA
Transcriptome
Issue Date: 2017
Publisher: Nature Publishing Group
Citation: Boral, D, Vishnoi, M, Liu, H.N, Yin, W, Sprouse, M.L, Scamardo, A, Hong, D.S, Tan, T.Z, Thiery, J.P, Chang, J.C, Marchetti, D (2017). Molecular characterization of breast cancer CTCs associated with brain metastasis. Nature Communications 8 (1) : 196. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-017-00196-1
Abstract: The enumeration of EpCAM-positive circulating tumor cells (CTCs) has allowed estimation of overall metastatic burden in breast cancer patients. However, a thorough understanding of CTCs associated with breast cancer brain metastasis (BCBM) is necessary for early identification and evaluation of treatment response to BCBM. Here we report that BCBM CTCs is enriched in a distinct sub-population of cells identifiable by their biomarker expression and mutational content. Deriving from a comprehensive analysis of CTC transcriptomes, we discovered a unique "circulating tumor cell gene signature" that is distinct from primary breast cancer tissues. Further dissection of the circulating tumor cell gene signature identified signaling pathways associated with BCBM CTCs that may have roles in potentiating BCBM. This study proposes CTC biomarkers and signaling pathways implicated in BCBM that may be used either as a screening tool for brain micro-metastasis detection or for making rational treatment decisions and monitoring therapeutic response in patients with BCBM. © 2017 The Author(s).
Source Title: Nature Communications
URI: https://scholarbank.nus.edu.sg/handle/10635/174407
ISSN: 2041-1723
DOI: 10.1038/s41467-017-00196-1
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