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https://doi.org/10.1038/s41467-017-00196-1
| Title: | Molecular characterization of breast cancer CTCs associated with brain metastasis | Authors: | Boral, D Vishnoi, M Liu, H.N Yin, W Sprouse, M.L Scamardo, A Hong, D.S Tan, T.Z Thiery, J.P Chang, J.C Marchetti, D |
Keywords: | biological marker CD86 antigen chemokine receptor CXCR4 cytokeratin epidermal growth factor receptor 2 epithelial cell adhesion molecule estrogen receptor Hermes antigen interleukin 1beta interleukin 8 Ki 67 antigen messenger RNA transcriptome epithelial cell adhesion molecule transcriptome tumor marker biomarker brain cancer cells and cell components gene gene expression mutation tumor advanced cancer apoptosis Article brain metastasis breast cancer CD4+ T lymphocyte CD8+ T lymphocyte cell isolation cell population cell proliferation cell subpopulation cell surface cell survival chemotaxis circulating tumor cell human human cell micrometastasis protein expression transcriptomics whole genome sequencing blood brain tumor breast tumor DNA sequence early cancer diagnosis female gene expression regulation genetics metabolism nucleotide sequence pathology procedures secondary tumor embolism Base Sequence Biomarkers, Tumor Brain Neoplasms Breast Neoplasms Early Detection of Cancer Epithelial Cell Adhesion Molecule Female Gene Expression Regulation, Neoplastic Humans Neoplastic Cells, Circulating Sequence Analysis, DNA Transcriptome |
Issue Date: | 2017 | Publisher: | Nature Publishing Group | Citation: | Boral, D, Vishnoi, M, Liu, H.N, Yin, W, Sprouse, M.L, Scamardo, A, Hong, D.S, Tan, T.Z, Thiery, J.P, Chang, J.C, Marchetti, D (2017). Molecular characterization of breast cancer CTCs associated with brain metastasis. Nature Communications 8 (1) : 196. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-017-00196-1 | Abstract: | The enumeration of EpCAM-positive circulating tumor cells (CTCs) has allowed estimation of overall metastatic burden in breast cancer patients. However, a thorough understanding of CTCs associated with breast cancer brain metastasis (BCBM) is necessary for early identification and evaluation of treatment response to BCBM. Here we report that BCBM CTCs is enriched in a distinct sub-population of cells identifiable by their biomarker expression and mutational content. Deriving from a comprehensive analysis of CTC transcriptomes, we discovered a unique "circulating tumor cell gene signature" that is distinct from primary breast cancer tissues. Further dissection of the circulating tumor cell gene signature identified signaling pathways associated with BCBM CTCs that may have roles in potentiating BCBM. This study proposes CTC biomarkers and signaling pathways implicated in BCBM that may be used either as a screening tool for brain micro-metastasis detection or for making rational treatment decisions and monitoring therapeutic response in patients with BCBM. © 2017 The Author(s). | Source Title: | Nature Communications | URI: | https://scholarbank.nus.edu.sg/handle/10635/174407 | ISSN: | 2041-1723 | DOI: | 10.1038/s41467-017-00196-1 |
| Appears in Collections: | Elements Staff Publications |
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