Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-017-06904-7
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dc.titleIkk2 regulates cytokinesis during vertebrate development
dc.contributor.authorShen, H
dc.contributor.authorShin, E.M
dc.contributor.authorLee, S
dc.contributor.authorMathavan, S
dc.contributor.authorKoh, H
dc.contributor.authorOsato, M
dc.contributor.authorChoi, H
dc.contributor.authorTergaonkar, V
dc.contributor.authorKorzh, V
dc.date.accessioned2020-09-04T03:35:36Z
dc.date.available2020-09-04T03:35:36Z
dc.date.issued2017
dc.identifier.citationShen, H, Shin, E.M, Lee, S, Mathavan, S, Koh, H, Osato, M, Choi, H, Tergaonkar, V, Korzh, V (2017). Ikk2 regulates cytokinesis during vertebrate development. Scientific Reports 7 (1) : 8094. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-06904-7
dc.identifier.issn2045-2322
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/174405
dc.description.abstractNF?B signaling has a pivotal role in regulation of development, innate immunity, and inflammation. Ikk2 is one of the two critical kinases that regulate the NF?B signaling pathway. While the role of Ikk2 in immunity, inflammation and oncogenesis has received attention, an understanding of the role of Ikk2 in vertebrate development has been compounded by the embryonic lethality seen in mice lacking Ikk2. We find that despite abnormal angiogenesis in IKK2 zygotic mutants of zebrafish, the maternal activity of Ikk2 supports embryogenesis and maturation of fertile animals and allows to study the role of IKK2 in development. Maternal-zygotic ikk2 mutants represent the first vertebrates globally devoid of maternal and zygotic Ikk2 activity. They are defective in cell proliferation as evidenced by abnormal cytokinesis, nuclear enlargement and syncytialisation of a significant portion of blastoderm. We further document that reduced phosphorylation of Aurora A by Ikk2 could underlie the basis of these defects in cell division. © 2017 The Author(s).
dc.publisherNature Publishing Group
dc.sourceUnpaywall 20200831
dc.subjectI kappa B kinase
dc.subjectimmunoglobulin enhancer binding protein
dc.subjectanimal
dc.subjectcell division
dc.subjectcell proliferation
dc.subjectcytokinesis
dc.subjectembryo development
dc.subjectfemale
dc.subjectgene expression regulation
dc.subjectmetabolism
dc.subjectphosphorylation
dc.subjectphysiology
dc.subjectsignal transduction
dc.subjecttransgenic animal
dc.subjectvertebrate
dc.subjectzebra fish
dc.subjectAnimals
dc.subjectAnimals, Genetically Modified
dc.subjectCell Division
dc.subjectCell Proliferation
dc.subjectCytokinesis
dc.subjectEmbryonic Development
dc.subjectFemale
dc.subjectGene Expression Regulation, Developmental
dc.subjectI-kappa B Kinase
dc.subjectNF-kappa B
dc.subjectPhosphorylation
dc.subjectSignal Transduction
dc.subjectVertebrates
dc.subjectZebrafish
dc.typeArticle
dc.contributor.departmentS'PORE NUCLEAR RSCH & SAFETY INITIATIVE
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.contributor.departmentDEPT OF BIOCHEMISTRY
dc.description.doi10.1038/s41598-017-06904-7
dc.description.sourcetitleScientific Reports
dc.description.volume7
dc.description.issue1
dc.description.page8094
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