Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-017-10529-1
Title: Activation of liver stromal cells is associated with male-biased liver tumor initiation in xmrk and Myc transgenic zebrafish
Authors: Yang, Q 
Yan, C 
Gong, Z 
Keywords: animal
cell transformation
disease model
female
gene expression regulation
genetics
immunology
liver cell carcinoma
liver tumor
macrophage
male
metabolism
neutrophil
oncogene
oncogene myc
pathology
sex factor
stroma cell
transgene
transgenic animal
zebra fish
Animals
Animals, Genetically Modified
Carcinoma, Hepatocellular
Cell Transformation, Neoplastic
Disease Models, Animal
Female
Gene Expression Regulation, Neoplastic
Genes, myc
Liver Neoplasms
Macrophages
Male
Neutrophils
Oncogenes
Sex Factors
Stromal Cells
Transgenes
Zebrafish
Issue Date: 2017
Publisher: Nature Publishing Group
Citation: Yang, Q, Yan, C, Gong, Z (2017). Activation of liver stromal cells is associated with male-biased liver tumor initiation in xmrk and Myc transgenic zebrafish. Scientific Reports 7 (1) : 10315. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-10529-1
Abstract: Hepatocellular carcinoma (HCC) is more prevalent in men than in women. Previously we have found that some stromal cells, including hepatic stellate cells (HSCs), neutrophils and macrophages, play crucial roles in promoting sex disparity in kras V12 -induced zebrafish HCC. The activation of HSCs is mediated by serotonin while activation of neutrophils and macrophages is mediated by cortisol. To ensure that these findings are also applicable to other oncogene induced tumors, stromal cell activation was compared between male and female fish during liver tumorigenesis initiated by xmrk or Myc oncogene. Consistently, we observed male-biased liver tumorigenesis in the xmrk and Myc models. In both models, there was a higher rate of HSC activation accompanied with a higher level of serotonin in male liver tumors. For tumor-infiltrated neutrophils and macrophages, significantly higher densities in male liver tumors were observed in both xmrk and Myc models. However, the male-biased increase of cortisol was observed only in xmrk- but not apparently in Myc expressing liver tumors. Overall, these observations are consistent with the observations in the kras liver tumor model, indicating that the serotonin- and cortisol-mediated pathways also play roles in sex disparity of liver tumors caused by other molecular pathways. © 2017 The Author(s).
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/174401
ISSN: 2045-2322
DOI: 10.1038/s41598-017-10529-1
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