Please use this identifier to cite or link to this item: https://doi.org/10.3390/v10110643
Title: Humanized mouse models for the study of infection and pathogenesis of human viruses
Authors: Lai, F 
Chen, Q 
Keywords: alpha2 interferon
gamma interferon
gamma interferon inducible protein 10
granulocyte macrophage colony stimulating factor
immunoglobulin M
interleukin 1 receptor
interleukin 15
interleukin 1alpha
interleukin 23
interleukin 3
monocyte chemotactic protein 1
tumor necrosis factor
adenosine deaminase deficiency
Dengue virus
Ebolavirus
Epstein Barr virus
Flavivirus
gene expression
Hantavirus
Hepatitis B virus
Hepatitis C virus
Hepatitis delta virus
Hepatitis E virus
human
Human immunodeficiency virus
immune response
immunotherapy
influenza
life cycle
liver cell
nonhuman
Review
signal transduction
virus cell interaction
virus infection
virus particle
virus pathogenesis
virus replication
virus transmission
animal
disease model
mouse
pathology
SCID mouse
virology
virus infection
Animals
Disease Models, Animal
Humans
Mice
Mice, SCID
Virus Diseases
Issue Date: 2018
Publisher: MDPI AG
Citation: Lai, F, Chen, Q (2018). Humanized mouse models for the study of infection and pathogenesis of human viruses. Viruses 10 (11) : 643. ScholarBank@NUS Repository. https://doi.org/10.3390/v10110643
Abstract: The evolution of infectious pathogens in humans proved to be a global health problem. Technological advancements over the last 50 years have allowed better means of identifying novel therapeutics to either prevent or combat these infectious diseases. The development of humanized mouse models offers a preclinical in vivo platform for further characterization of human viral infections and human immune responses triggered by these virus particles. Multiple strains of immunocompromised mice reconstituted with a human immune system and/or human hepatocytes are susceptible to infectious pathogens as evidenced by establishment of full viral life cycles in hope of investigating viral–host interactions observed in patients and discovering potential immunotherapies. This review highlights recent progress in utilizing humanized mice to decipher human specific immune responses against viral tropism. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: Viruses
URI: https://scholarbank.nus.edu.sg/handle/10635/174351
ISSN: 1999-4915
DOI: 10.3390/v10110643
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