Please use this identifier to cite or link to this item:
https://doi.org/10.1186/1471-2164-15-S9-S20
DC Field | Value | |
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dc.title | Novel SNP improves differential survivability and mortality in non-small cell lung cancer patients | |
dc.contributor.author | Mah, T.L | |
dc.contributor.author | Yap, X.N.A | |
dc.contributor.author | Limviphuvadh, V | |
dc.contributor.author | Li, N | |
dc.contributor.author | Sridharan, S | |
dc.contributor.author | Kuralmani, V | |
dc.contributor.author | Feng, M | |
dc.contributor.author | Liem, N | |
dc.contributor.author | Adhikari, S | |
dc.contributor.author | Yong, W.P | |
dc.contributor.author | Soo, R.A | |
dc.contributor.author | Maurer-Stroh, S | |
dc.contributor.author | Eisenhaber, F | |
dc.contributor.author | Tong, J.C | |
dc.date.accessioned | 2020-09-04T02:12:02Z | |
dc.date.available | 2020-09-04T02:12:02Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Mah, T.L, Yap, X.N.A, Limviphuvadh, V, Li, N, Sridharan, S, Kuralmani, V, Feng, M, Liem, N, Adhikari, S, Yong, W.P, Soo, R.A, Maurer-Stroh, S, Eisenhaber, F, Tong, J.C (2014). Novel SNP improves differential survivability and mortality in non-small cell lung cancer patients. BMC Genomics 15 (9) : S20. ScholarBank@NUS Repository. https://doi.org/10.1186/1471-2164-15-S9-S20 | |
dc.identifier.issn | 14712164 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/174295 | |
dc.description.abstract | Background: Non-small cell lung cancer (NSCLC) is a major cause of cancer-related death worldwide due to poor patient prognosis and clinical outcome. Here, we studied the genetic variations underlying NSCLC pathogenesis based on their association to patient outcome after gemcitabine therapy. Results: Bioinformatics analysis was used to investigate possible effects of POLA2 G583R (POLA2+1747 GG/GA, dbSNP ID: rs487989) in terms of protein function. Using biostatistics, POLA2+1747 GG/GA (rs487989, POLA2 G583R) was identified as strongly associated with mortality rate and survival time among NSCLC patients. It was also shown that POLA2+1747 GG/GA is functionally significant for protein localization via green fluorescent protein (GFP)-tagging and confocal laser scanning microscopy analysis. The single nucleotide polymorphism (SNP) causes DNA polymerase alpha subunit B to localize in the cytoplasm instead of the nucleus. This inhibits DNA replication in cancer cells and confers a protective effect in individuals with this SNP. Conclusions: The results suggest that POLA2+1747 GG/GA may be used as a prognostic biomarker of patient outcome in NSCLC pathogenesis. © 2014 Mah et al.; licensee BioMed Central Ltd. | |
dc.publisher | BioMed Central Ltd. | |
dc.source | Unpaywall 20200831 | |
dc.subject | DNA directed DNA polymerase alpha | |
dc.subject | gemcitabine | |
dc.subject | deoxycytidine | |
dc.subject | DNA directed DNA polymerase beta | |
dc.subject | gemcitabine | |
dc.subject | tumor marker | |
dc.subject | adult | |
dc.subject | aged | |
dc.subject | Article | |
dc.subject | cancer mortality | |
dc.subject | cancer survival | |
dc.subject | carcinogenesis | |
dc.subject | cellular distribution | |
dc.subject | clinical article | |
dc.subject | confocal laser microscopy | |
dc.subject | controlled study | |
dc.subject | DNA replication | |
dc.subject | female | |
dc.subject | genetic association | |
dc.subject | genetic variability | |
dc.subject | human | |
dc.subject | human cell | |
dc.subject | male | |
dc.subject | non small cell lung cancer | |
dc.subject | oncogene | |
dc.subject | outcome assessment | |
dc.subject | overall survival | |
dc.subject | POLA2 gene | |
dc.subject | protein analysis | |
dc.subject | protein localization | |
dc.subject | single nucleotide polymorphism | |
dc.subject | survival time | |
dc.subject | active transport | |
dc.subject | analogs and derivatives | |
dc.subject | biology | |
dc.subject | Carcinoma, Non-Small-Cell Lung | |
dc.subject | cell nucleus | |
dc.subject | chemical structure | |
dc.subject | chemistry | |
dc.subject | genetics | |
dc.subject | genotype | |
dc.subject | Lung Neoplasms | |
dc.subject | metabolism | |
dc.subject | middle aged | |
dc.subject | mortality | |
dc.subject | mutation | |
dc.subject | prognosis | |
dc.subject | protein conformation | |
dc.subject | survival | |
dc.subject | Active Transport, Cell Nucleus | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Biomarkers, Tumor | |
dc.subject | Carcinoma, Non-Small-Cell Lung | |
dc.subject | Cell Nucleus | |
dc.subject | Computational Biology | |
dc.subject | Deoxycytidine | |
dc.subject | DNA Polymerase I | |
dc.subject | Female | |
dc.subject | Genotype | |
dc.subject | Humans | |
dc.subject | Lung Neoplasms | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | Models, Molecular | |
dc.subject | Mutation | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | Prognosis | |
dc.subject | Protein Conformation | |
dc.subject | Survival Analysis | |
dc.type | Article | |
dc.contributor.department | CANCER SCIENCE INSTITUTE OF SINGAPORE | |
dc.contributor.department | BIOCHEMISTRY | |
dc.contributor.department | BIOLOGICAL SCIENCES | |
dc.contributor.department | SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH | |
dc.description.doi | 10.1186/1471-2164-15-S9-S20 | |
dc.description.sourcetitle | BMC Genomics | |
dc.description.volume | 15 | |
dc.description.issue | 9 | |
dc.description.page | S20 | |
dc.published.state | Published | |
Appears in Collections: | Elements Staff Publications |
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