Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-018-26456-8
Title: Dissecting Clinical and Metabolomics Associations of Left Atrial Phasic Function by Cardiac Magnetic Resonance Feature Tracking
Authors: Koh A.S. 
Gao F. 
Leng S.
Kovalik J.-P. 
Zhao X.
Tan R.S. 
Fridianto K.T. 
Ching J. 
Chua S.J.M.
Yuan J.-M. 
Koh W.-P.
Zhong L. 
Keywords: aged
diagnostic imaging
female
heart
heart atrium function
human
image processing
male
metabolomics
nuclear magnetic resonance imaging
Aged
Atrial Function, Left
Female
Heart
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Metabolomics
Issue Date: 2018
Publisher: Nature Publishing Group
Citation: Koh A.S., Gao F., Leng S., Kovalik J.-P., Zhao X., Tan R.S., Fridianto K.T., Ching J., Chua S.J.M., Yuan J.-M., Koh W.-P., Zhong L. (2018). Dissecting Clinical and Metabolomics Associations of Left Atrial Phasic Function by Cardiac Magnetic Resonance Feature Tracking. Scientific Reports 8 (1) : 8138. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-018-26456-8
Abstract: Among community cohorts, associations between clinical and metabolite factors and complex left atrial (LA) phasic function assessed by cardiac magnetic resonance (CMR) feature tracking (FT) are unknown. Longitudinal LA strain comprising reservoir strain (?s), conduit strain (?e) and booster strain (?a) and their corresponding peak strain rates (SRs, SRe, SRa) were measured using CMR FT. Targeted mass spectrometry measured 83 circulating metabolites in serum. Sparse Principal Component Analysis was used for data reduction. Among community adults (n = 128, 41% female) (mean age: 70.5 ± 11.6 years), age was significantly associated with ?s (? = -0.30, p < 0.0001), ?e (? = -0.3, p < 0.0001), SRs (? = -0.02, p < 0.0001), SRe (? = 0.04, p < 0.0001) and SRe/SRa (? = -0.01, p = 0.012). In contrast, heart rate was significantly associated with ?a (? = 0.1, p = 0.001) and SRa (? = -0.02, p < 0.0001). Serine was significantly associated with ?s (? = 10.1, p = 0.015), SRs (? = 0.5, p = 0.033) and SRa (? = -0.9, p = 0.016). Citrulline was associated with ?s (? = -4.0, p = 0.016), ?a (? = -3.4, p = 0.002) and SRa (? = 0.4, p = 0.019). Valine was associated with ratio of SRe:SRa (? = -0.4, p = 0.039). Medium and long chain dicarboxyl carnitines were associated with ?s (? = -0.6, p = 0.038). Phases of LA function were differentially associated with clinical and metabolite factors. Metabolite signals may be used to advance mechanistic understanding of LA disease in future studies. © 2018 The Author(s).
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/174219
ISSN: 2045-2322
DOI: 10.1038/s41598-018-26456-8
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