Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-018-30442-5
Title: Biological significance and prognostic relevance of peripheral blood neutrophil-to-lymphocyte ratio in soft tissue sarcoma
Authors: Chan, J.Y 
Zhang, Z
Chew, W
Tan, G.F
Lim, C.L
Zhou, L
Goh, W.L
Poon, E
Somasundaram, N
Selvarajan, S 
Sittampalam, K
Chin, F 
Teh, J
Tan, M.H 
Soo, K.C 
Teo, M 
Farid, M 
Quek, R 
Keywords: biological marker
adolescent
adult
aged
blood
cancer grading
cancer staging
comorbidity
female
human
leukocyte count
lymphocyte
lymphocyte count
male
middle aged
mortality
neutrophil
platelet count
prognosis
receiver operating characteristic
sarcoma
survival analysis
very elderly
young adult
Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers
Comorbidity
Female
Humans
Leukocyte Count
Lymphocyte Count
Lymphocytes
Male
Middle Aged
Neoplasm Grading
Neoplasm Staging
Neutrophils
Platelet Count
Prognosis
ROC Curve
Sarcoma
Survival Analysis
Young Adult
Issue Date: 2018
Publisher: Nature Publishing Group
Citation: Chan, J.Y, Zhang, Z, Chew, W, Tan, G.F, Lim, C.L, Zhou, L, Goh, W.L, Poon, E, Somasundaram, N, Selvarajan, S, Sittampalam, K, Chin, F, Teh, J, Tan, M.H, Soo, K.C, Teo, M, Farid, M, Quek, R (2018). Biological significance and prognostic relevance of peripheral blood neutrophil-to-lymphocyte ratio in soft tissue sarcoma. Scientific Reports 8 (1) : 11959. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-018-30442-5
Abstract: Peripheral blood indices of systemic inflammation such as the neutrophil-lymphocyte ratio (NLR) have been shown to be prognostic in various cancers. We aim to investigate the clinical significance of these indices in patients with soft tissue sarcoma (STS). Seven hundred and twelve patients with available blood counts at diagnosis and/or metastatic relapse were retrospectively examined. An optimal cutoff for NLR-high (>2.5) in predicting overall survival (OS) was determined using receiver operating curve analyses. Survival analyses were performed using the Kaplan-Meier method and multivariate Cox proportional models. Our results show that NLR was significantly higher in patients with distant metastasis at diagnosis (n = 183) compared to those without (n = 529) (median: 4.36 vs 2.85, p < 0.0001). Progression of localized disease at diagnosis to metastatic relapse within the same patients was associated with an interval increase in NLR (median: 3.21 vs 3.74, p = 0.0003). In multivariate analysis, NLR-high was the only consistent factor independently associated with both worse OS (HR 1.53, 95% CI 1.10–2.13, p = 0.0112) and relapse-free survival (HR 1.41, 95% CI 1.08–1.85, p = 0.0125) in localized disease, as well as OS (HR 1.82, 95% CI 1.16–2.85, p = 0.0087) in metastatic/unresectable disease. In conclusion, high NLR is an independent marker of poor prognosis among patients with STS. © 2018, The Author(s).
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/174211
ISSN: 2045-2322
DOI: 10.1038/s41598-018-30442-5
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