Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-018-34834-5
Title: Altered Placental Chorionic Arterial Biomechanical Properties During Intrauterine Growth Restriction
Authors: Saw, S.N 
Tay, J.J.H
Poh, Y.W
Yang, L
Tan, W.C 
Tan, L.K 
Clark, A
Biswas, A 
Mattar, C.N.Z 
Yap, C.H 
Keywords: artery
biological model
biomechanics
chorion villus
female
hemodynamics
human
intrauterine growth retardation
pathophysiology
placenta circulation
pregnancy
prevalence
pulse wave
vascularization
Arteries
Biomechanical Phenomena
Chorionic Villi
Female
Fetal Growth Retardation
Hemodynamics
Humans
Models, Biological
Placental Circulation
Pregnancy
Prevalence
Pulse Wave Analysis
Issue Date: 2018
Publisher: Nature Publishing Group
Citation: Saw, S.N, Tay, J.J.H, Poh, Y.W, Yang, L, Tan, W.C, Tan, L.K, Clark, A, Biswas, A, Mattar, C.N.Z, Yap, C.H (2018). Altered Placental Chorionic Arterial Biomechanical Properties During Intrauterine Growth Restriction. Scientific Reports 8 (1) : 16526. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-018-34834-5
Abstract: Intrauterine growth restriction (IUGR) is a pregnancy complication due to placental dysfunction that prevents the fetus from obtaining enough oxygen and nutrients, leading to serious mortality and morbidity risks. There is no treatment for IUGR despite having a prevalence of 3% in developed countries, giving rise to an urgency to improve our understanding of the disease. Applying biomechanics investigation on IUGR placental tissues can give important new insights. We performed pressure-diameter mechanical testing of placental chorionic arteries and found that in severe IUGR cases (RI > 90th centile) but not in IUGR cases (RI < 90th centile), vascular distensibility was significantly increased from normal. Constitutive modeling demonstrated that a simplified Fung-type hyperelastic model was able to describe the mechanical properties well, and histology showed that severe IUGR had the lowest collagen to elastin ratio. To demonstrate that the increased distensibility in the severe IUGR group was related to their elevated umbilical resistance and pulsatility indices, we modelled the placental circulation using a Windkessel model, and demonstrated that vascular compliance (and not just vascular resistance) directly affected blood flow pulsatility, suggesting that it is an important parameter for the disease. Our study showed that biomechanics study on placenta could extend our understanding on placenta physiology. © 2018, The Author(s).
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/174195
ISSN: 2045-2322
DOI: 10.1038/s41598-018-34834-5
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