Please use this identifier to cite or link to this item: https://doi.org/10.1186/s13045-015-0129-1
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dc.titleCompeting endogenous RNA networks: Tying the essential knots for cancer biology and therapeutics
dc.contributor.authorSanchez-Mejias, A
dc.contributor.authorTay, Y
dc.date.accessioned2020-09-03T10:37:08Z
dc.date.available2020-09-03T10:37:08Z
dc.date.issued2015
dc.identifier.citationSanchez-Mejias, A, Tay, Y (2015). Competing endogenous RNA networks: Tying the essential knots for cancer biology and therapeutics. Journal of Hematology and Oncology 8 (1) : 30. ScholarBank@NUS Repository. https://doi.org/10.1186/s13045-015-0129-1
dc.identifier.issn17568722
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/174139
dc.description.abstractA recently discovered dimension of post-transcriptional gene regulation involves co-regulatory crosstalk between RNA transcripts, which compete for common pools of microRNA (miRNA) molecules. These competing endogenous RNAs (ceRNAs), or natural miRNA sponges, have an active role in regulating miRNA availability within the cell and form intertwined regulatory networks. Recent reports have implicated diverse RNA species including protein-coding messenger RNAs and non-coding RNAs as ceRNAs in human development and diseases including human cancer. In this review, we discuss the most recent discoveries that implicate natural miRNA decoys in human cancer biology, as well as exciting advances in the study of ceRNA networks and dynamics. The structure and topology of intricate genome-scale ceRNA networks can be predicted computationally, and their dynamic response to fluctuations in ceRNA and miRNA levels can be studied via mathematical modeling. Additionally, the development of new methods to quantitatively determine absolute expression levels of miRNA and ceRNA molecules have expanded the capacity to accurately study the efficiency of ceRNA crosstalk in diverse biological models. These major milestones are of critical importance to identify key components of ceRNA regulatory networks that could aid the development of new approaches to cancer diagnostics and oligonucleotide-based therapeutics. © 2015 Sanchez-Mejias and Tay; licensee BioMed Central.
dc.sourceUnpaywall 20200831
dc.subjectB Raf kinase
dc.subjectcompeting endogenous rna
dc.subjectlong untranslated RNA
dc.subjectmessenger RNA
dc.subjectmicroRNA
dc.subjectmicroRNA 1
dc.subjectmicroRNA 101
dc.subjectmicroRNA 122
dc.subjectmicroRNA 182
dc.subjectmitogen activated protein kinase
dc.subjectRNA
dc.subjectsmall untranslated RNA
dc.subjecttranscription factor
dc.subjectunclassified drug
dc.subjectuntranslated RNA
dc.subjectRNA
dc.subjectbinding affinity
dc.subjectbiological model
dc.subjectbreast cancer
dc.subjectcancer growth
dc.subjectcancer research
dc.subjectcancer therapy
dc.subjectcellular distribution
dc.subjectchromosome rearrangement
dc.subjectcolorectal cancer
dc.subjectendometrium cancer
dc.subjectgene control
dc.subjectgene expression
dc.subjectgene regulatory network
dc.subjectglioblastoma
dc.subjecthuman
dc.subjecthuman development
dc.subjectliver cancer
dc.subjectlymphoma
dc.subjectmathematical model
dc.subjectmelanoma
dc.subjectmolecular dynamics
dc.subjectmolecular interaction
dc.subjectnonhuman
dc.subjectprostate cancer
dc.subjectregulatory mechanism
dc.subjectReview
dc.subjectsomatic mutation
dc.subjectstomach cancer
dc.subjectupregulation
dc.subjectanimal
dc.subjectgene expression regulation
dc.subjectgenetics
dc.subjectneoplasm
dc.subjectAnimals
dc.subjectGene Expression Regulation, Neoplastic
dc.subjectGene Regulatory Networks
dc.subjectHumans
dc.subjectNeoplasms
dc.subjectRNA
dc.typeReview
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.contributor.departmentDEPT OF BIOCHEMISTRY
dc.description.doi10.1186/s13045-015-0129-1
dc.description.sourcetitleJournal of Hematology and Oncology
dc.description.volume8
dc.description.issue1
dc.description.page30
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