Please use this identifier to cite or link to this item: https://doi.org/10.3389/fendo.2016.00065
Title: Exercise and adipose tissue macrophages: New Frontiers in obesity research?
Authors: Goh J. 
Goh K.P.
Abbasi A.
Keywords: arginase 1
biological marker
colony stimulating factor 1
fatty acid
gamma interferon
granulocyte macrophage colony stimulating factor
inducible nitric oxide synthase
interleukin 10
interleukin 4
mammalian target of rapamycin
stress activated protein kinase
tumor necrosis factor
adaptive immunity
adipose tissue
antiinflammatory activity
Article
cell stress
endurance training
exercise
gene expression
hepatitis
human
immune response
immune system
innate immunity
macrophage
macrophage activation
microenvironment
myositis
nonhuman
obesity
polarization
protein expression
protein synthesis
soft tissue inflammation
Issue Date: 2016
Citation: Goh J., Goh K.P., Abbasi A. (2016). Exercise and adipose tissue macrophages: New Frontiers in obesity research?. Frontiers in Endocrinology 7 : 65. ScholarBank@NUS Repository. https://doi.org/10.3389/fendo.2016.00065
Abstract: Obesity is a major public health problem in the twenty-first century. Mutations in genes that regulate substrate metabolism, subsequent dysfunction in their protein products, and other factors, such as increased adipose tissue inflammation, are some underlying etiologies of this disease. Increased inflammation in the adipose tissue microenvironment is partly mediated by the presence of cells from the innate and adaptive immune system. A subset of the innate immune population in adipose tissue include macrophages, termed adipose tissue macrophages (ATMs), which are central players in adipose tissue inflammation. Being extremely plastic, their responses to diverse molecular signals in the microenvironment dictate their identity and functional properties, where they become either pro-inflammatory (M1) or anti-inflammatory (M2). Endurance exercise training exerts global anti-inflammatory responses in multiple organs, including skeletal muscle, liver, and adipose tissue. The purpose of this review is to discuss the different mechanisms that drive ATM-mediated inflammation in obesity and present current evidence of how exercise training, specifically endurance exercise training, modulates the polarization of ATMs from an M1 to an M2 anti-inflammatory phenotype. © 2016 Goh, Goh and Abbasi.
Source Title: Frontiers in Endocrinology
URI: https://scholarbank.nus.edu.sg/handle/10635/174101
ISSN: 16642392
DOI: 10.3389/fendo.2016.00065
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