Please use this identifier to cite or link to this item:
Title: Exercise and adipose tissue macrophages: New Frontiers in obesity research?
Authors: Goh J. 
Goh K.P.
Abbasi A.
Keywords: arginase 1
biological marker
colony stimulating factor 1
fatty acid
gamma interferon
granulocyte macrophage colony stimulating factor
inducible nitric oxide synthase
interleukin 10
interleukin 4
mammalian target of rapamycin
stress activated protein kinase
tumor necrosis factor
adaptive immunity
adipose tissue
antiinflammatory activity
cell stress
endurance training
gene expression
immune response
immune system
innate immunity
macrophage activation
protein expression
protein synthesis
soft tissue inflammation
Issue Date: 2016
Citation: Goh J., Goh K.P., Abbasi A. (2016). Exercise and adipose tissue macrophages: New Frontiers in obesity research?. Frontiers in Endocrinology 7 : 65. ScholarBank@NUS Repository.
Abstract: Obesity is a major public health problem in the twenty-first century. Mutations in genes that regulate substrate metabolism, subsequent dysfunction in their protein products, and other factors, such as increased adipose tissue inflammation, are some underlying etiologies of this disease. Increased inflammation in the adipose tissue microenvironment is partly mediated by the presence of cells from the innate and adaptive immune system. A subset of the innate immune population in adipose tissue include macrophages, termed adipose tissue macrophages (ATMs), which are central players in adipose tissue inflammation. Being extremely plastic, their responses to diverse molecular signals in the microenvironment dictate their identity and functional properties, where they become either pro-inflammatory (M1) or anti-inflammatory (M2). Endurance exercise training exerts global anti-inflammatory responses in multiple organs, including skeletal muscle, liver, and adipose tissue. The purpose of this review is to discuss the different mechanisms that drive ATM-mediated inflammation in obesity and present current evidence of how exercise training, specifically endurance exercise training, modulates the polarization of ATMs from an M1 to an M2 anti-inflammatory phenotype. © 2016 Goh, Goh and Abbasi.
Source Title: Frontiers in Endocrinology
ISSN: 16642392
DOI: 10.3389/fendo.2016.00065
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_3389_fendo_2016_00065.pdf524.72 kBAdobe PDF



Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.