Please use this identifier to cite or link to this item: https://doi.org/10.18632/oncotarget.8875
Title: ANXA1 inhibits miRNA-196a in a negative feedback loop through NF-kB and C-Myc to reduce breast cancer proliferation
Authors: Yuan, Y 
Anbalagan, D
Lee, L.H
Samy, R.P 
Shanmugam, M.K 
Kumar, A.P 
Sethi, G 
Lobie, P.E 
Lim, L.H.K 
Keywords: annexin
annexin 1
estrogen receptor
immunoglobulin enhancer binding protein
microRNA
microRNA 196a
Myc protein
synaptotagmin I
unclassified drug
immunoglobulin enhancer binding protein
lipocortin 1
microRNA
MIRN196 microRNA, human
Myc protein
MYC protein, human
Article
breast cancer
cancer inhibition
cell proliferation
controlled study
gene expression
human
human cell
in vivo study
MCF 7 cell line
protein function
RNA transcription
tumor growth
animal
Bagg albino mouse
breast tumor
cell proliferation
female
gene expression regulation
genetics
MCF-7 cell line
metabolism
nude mouse
pathology
physiological feedback
RNA interference
tumor cell line
tumor volume
xenograft
Animals
Annexin A1
Breast Neoplasms
Cell Line, Tumor
Cell Proliferation
Feedback, Physiological
Female
Gene Expression Regulation, Neoplastic
Humans
MCF-7 Cells
Mice, Inbred BALB C
Mice, Nude
MicroRNAs
NF-kappa B
Proto-Oncogene Proteins c-myc
RNA Interference
Transplantation, Heterologous
Tumor Burden
Issue Date: 2016
Citation: Yuan, Y, Anbalagan, D, Lee, L.H, Samy, R.P, Shanmugam, M.K, Kumar, A.P, Sethi, G, Lobie, P.E, Lim, L.H.K (2016). ANXA1 inhibits miRNA-196a in a negative feedback loop through NF-kB and C-Myc to reduce breast cancer proliferation. Oncotarget 7 (19) : 27007-27020. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.8875
Abstract: MiRNAs are endogenous ~22 nt RNAs which play critical regulatory roles in a wide range of biological and pathological processes, which can act as oncogenes or tumor suppressor genes depending on their target genes. We have recently shown that ANXA1 inhibits the expression of miRNAs including miR196a. Here, we show that miR196a was highly expressed in ER+ MCF-7 breast cancer cells when compared to normal mammary gland cells, with expression levels negatively correlating to ANXA1. ANXA1 inhibits the biogenesis of oncogenic miR-196a by suppressing primarymiR196a indirectly through the stimulation of c-myc and NFkB expression and activity in breast cancer cells. In a negative feedback loop, miR-196a directly inhibits ANXA1 and enhances breast cancer cell proliferation in vitro. Finally, miR196a promotes breast tumor growth in vivo. This study reports a novel regulatory circuit between ANXA1, NF-kB, c-myc and miR-196a which regulates breast cancer cell proliferation and tumor growth.
Source Title: Oncotarget
URI: https://scholarbank.nus.edu.sg/handle/10635/174092
ISSN: 19492553
DOI: 10.18632/oncotarget.8875
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