Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep22231
Title: Early cerebral volume reductions and their associations with reduced lupus disease activity in patients with newly-diagnosed systemic lupus erythematosus
Authors: Mak, A 
Ho, R.C.-M 
Tng, H.-Y 
Koh, H.L 
Chong, J.S.X 
Zhou, J 
Keywords: antinuclear antibody
adult
blood
diagnostic imaging
disease course
female
gray matter
human
Lupus Erythematosus, Systemic
male
middle aged
nuclear magnetic resonance imaging
organ size
pathology
white matter
Adult
Antibodies, Antinuclear
Disease Progression
Female
Gray Matter
Humans
Lupus Erythematosus, Systemic
Magnetic Resonance Imaging
Male
Middle Aged
Organ Size
White Matter
Issue Date: 2016
Citation: Mak, A, Ho, R.C.-M, Tng, H.-Y, Koh, H.L, Chong, J.S.X, Zhou, J (2016). Early cerebral volume reductions and their associations with reduced lupus disease activity in patients with newly-diagnosed systemic lupus erythematosus. Scientific Reports 6 : 22231. ScholarBank@NUS Repository. https://doi.org/10.1038/srep22231
Abstract: We examined if cerebral volume reduction occurs very early during the course of systemic lupus erythematosus (SLE), and observed prospectively whether gray (GMV) and white matter volumes (WMV) of the brain would improve with lowered SLE disease activity. T1-weighted MRI brain images were obtained from 14 healthy controls (HC) and 14 newly-diagnosed SLE patients within 5 months of diagnosis (S1) and after achieving low disease activity (S2). Whole brain voxel-based morphometry was used to detect differences in the GMV and WMV between SLE patients and HC and those between SLE patients at S1 and S2. SLE patients were found to have lower GMV than HC in the middle cingulate cortex, middle frontal gyrus and right supplementary motor area, and lower WMV in the superior longitudinal fasciculus, cingulum cingulate gyrus and inferior fronto-occipital fasciculus at both S1 and S2. Whole-brain voxel-wise analysis revealed increased GMV chiefly in the prefrontal regions at S2 compared to S1 in SLE patients. The GMV increase in the left superior frontal gyrus was significantly associated with lowered SLE disease activity. In conclusion, GMV and WMV reduced very early in SLE patients. Reduction of SLE disease activity was accompanied by region-specific GMV improvement in the prefrontal regions.
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/174019
ISSN: 20452322
DOI: 10.1038/srep22231
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1038_srep22231.pdf1.19 MBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

7
checked on Apr 15, 2021

Page view(s)

56
checked on Apr 16, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.