Please use this identifier to cite or link to this item: https://doi.org/10.1186/s12902-017-0159-5
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dc.titleHigh-sensitive C-reactive protein and risk of incident type 2 diabetes: A case-control study nested within the Singapore Chinese Health Study
dc.contributor.authorPan, A
dc.contributor.authorWang, Y
dc.contributor.authorYuan, J.-M
dc.contributor.authorKoh, W.-P
dc.date.accessioned2020-09-01T08:00:21Z
dc.date.available2020-09-01T08:00:21Z
dc.date.issued2017
dc.identifier.citationPan, A, Wang, Y, Yuan, J.-M, Koh, W.-P (2017). High-sensitive C-reactive protein and risk of incident type 2 diabetes: A case-control study nested within the Singapore Chinese Health Study. BMC Endocrine Disorders 17 (1) : 8. ScholarBank@NUS Repository. https://doi.org/10.1186/s12902-017-0159-5
dc.identifier.issn14726823
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/173865
dc.description.abstractBackground: The liver-derived C-reactive protein (CRP) is a sensitive and systemic biomarker of inflammation, and has been associated with increased risk of developing type 2 diabetes in populations other than Chinese. Therefore, we prospectively examined the relation between plasma levels of CRP and risk of type 2 diabetes (T2D) among a Chinese population. Methods: Plasma high-sensitive CRP (hs-CRP) concentrations were assayed among 571 T2D cases and 571 controls nested in the prospective cohort of the Singapore Chinese Health Study. Both cases and controls were free of physician-diagnosed diabetes, cardiovascular disease and cancer at blood collections (1999-2004). Incident physician-diagnosed T2D cases were self-reported during the follow-up visits (2006-2010), and controls were matched for age (±3 years) and date (±6 months) of blood collection and gender. Multivariable logistic regression models were used to compute the odds ratio (OR) and the corresponding 95% confidence intervals (CIs). Results: The mean (SD) concentrations of hs-CRP were 2.79 (2.65) and 1.86 (2.03) mg/L, respectively, in cases and controls (P < 0.001). After multivariate adjustment for T2D risk factors such as lifestyle, body mass index, plasma triglycerides and HDL cholesterol, the OR comparing the extreme quartiles of hs-CRP was 1.74 [95% CI 1.12-2.70; P for trend = 0.016]. When the analysis was limited to 279 cases who had HbA1c ?6.5% at the time of blood collection and their controls, the OR comparing the extreme quartiles of hs-CRP was 2.43 (95% CI 1.25-4.71; P for trend = 0.003). When confined to the other 292 subjects with HbA1c <6.5% and their controls, the corresponding OR was 1.24 (95% CI 0.64-2.39; P for trend = 0.93). Conclusions: We found that CRP was not associated with increased risk of incident diabetes in this cohort of Chinese in Singapore. Previous positive findings from prospective studies might be partly due to undiagnosed T2D among the cases during blood collection. © 2017 The Author(s).
dc.publisherBioMed Central Ltd.
dc.sourceUnpaywall 20200831
dc.subjectC reactive protein
dc.subjecthemoglobin A1c
dc.subjecthigh density lipoprotein cholesterol
dc.subjecthigh sensitive C reactive protein
dc.subjecttriacylglycerol
dc.subjectunclassified drug
dc.subjectbiological marker
dc.subjectC reactive protein
dc.subjectadult
dc.subjectArticle
dc.subjectbody mass
dc.subjectChinese
dc.subjectcholesterol blood level
dc.subjectcontrolled study
dc.subjectfemale
dc.subjecthuman
dc.subjectlifestyle
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectnon insulin dependent diabetes mellitus
dc.subjectpopulation based case control study
dc.subjectprospective study
dc.subjectprotein blood level
dc.subjectrisk assessment
dc.subjectrisk factor
dc.subjectself report
dc.subjectSingaporean
dc.subjecttriacylglycerol blood level
dc.subjectaged
dc.subjectblood
dc.subjectcase control study
dc.subjectChina
dc.subjectconfidence interval
dc.subjectDiabetes Mellitus, Type 2
dc.subjectincidence
dc.subjectmetabolism
dc.subjectmiddle aged
dc.subjectmultivariate analysis
dc.subjectodds ratio
dc.subjectstatistical model
dc.subjectAged
dc.subjectBiomarkers
dc.subjectC-Reactive Protein
dc.subjectCase-Control Studies
dc.subjectChina
dc.subjectConfidence Intervals
dc.subjectDiabetes Mellitus, Type 2
dc.subjectFemale
dc.subjectHumans
dc.subjectIncidence
dc.subjectLogistic Models
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMultivariate Analysis
dc.subjectOdds Ratio
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.contributor.departmentLIFE SCIENCES INSTITUTE
dc.description.doi10.1186/s12902-017-0159-5
dc.description.sourcetitleBMC Endocrine Disorders
dc.description.volume17
dc.description.issue1
dc.description.page8
dc.published.statePublished
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