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Title: Synthetic genetic polymers: Advances and applications
Authors: Ma, Q 
Lee, D
Tan, Y.Q 
Wong, G 
Gao, Z 
Keywords: Biomolecules
Natural polymers
Nucleic acids
Chemically modified
Entry point
Perennial problems
Synthetic chemists
Technical applications
Issue Date: 2016
Citation: Ma, Q, Lee, D, Tan, Y.Q, Wong, G, Gao, Z (2016). Synthetic genetic polymers: Advances and applications. Polymer Chemistry 7 (33) : 5199-5216. ScholarBank@NUS Repository.
Abstract: Synthetic genetic polymers, also known as xeno-nucleic acids (XNAs), are chemically modified or synthesized analogues of natural nucleic acids. Initially developed by synthetic chemists to better understand nucleic acids, XNAs have grown rapidly over the last two decades in both diversity and usefulness. Their tailor-made functionalities allow them to overcome perennial problems in using natural nucleic acids in technical applications. In this article, key milestones in XNA research are reviewed through highlighting representative examples. The advantages of using XNAs over natural nucleic acids are discussed. It is hoped that this article will provide a summary of the advances and current understanding of XNAs in addition to their technical applications, serving as an entry point to those who are interested in the synthesis and application of XNAs. Besides interesting results, challenges encountered may inspire researchers to perfect the synthesis of XNAs and tailor their functionalities. © 2016 The Royal Society of Chemistry.
Source Title: Polymer Chemistry
ISSN: 17599954
DOI: 10.1039/c6py01075j
Appears in Collections:Staff Publications

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