Please use this identifier to cite or link to this item: https://doi.org/10.3389/fmicb.2017.01415
Title: Dengue virus glycosylation: What do we know?
Authors: Yap, S.S.L 
Nguyen-Khuong, T
Rudd, P.M
Alonso, S 
Keywords: castanospermine 6 butyrate
complement component C3b
complement component C4b
envelope protein
glycan
lectin receptor
nonstructural protein 1
Aedes
blood vessel permeability
complement activation
dengue
Dengue virus
glycobiology
human
immune evasion
immunosurveillance
insect cell
mammal cell
membrane fusion
nonhuman
protein glycosylation
protein secretion
proteomics
Review
sequence alignment
thrombocytopenia
vaccine immunogenicity
virus attachment
virus cell interaction
virus entry
virus genome
virus particle
virus pathogenesis
virus replication
virus transmission
virus virulence
Issue Date: 2017
Citation: Yap, S.S.L, Nguyen-Khuong, T, Rudd, P.M, Alonso, S (2017). Dengue virus glycosylation: What do we know?. Frontiers in Microbiology 8 (JUL) : 1415. ScholarBank@NUS Repository. https://doi.org/10.3389/fmicb.2017.01415
Abstract: In many infectious diseases caused by either viruses or bacteria, pathogen glycoproteins play important roles during the infection cycle, ranging from entry to successful intracellular replication and host immune evasion. Dengue is no exception. Dengue virus glycoproteins, envelope protein (E) and non-structural protein 1 (NS1) are two popular sub-unit vaccine candidates. E protein on the virion surface is the major target of neutralizing antibodies. NS1 which is secreted during DENV infection has been shown to induce a variety of host responses through its binding to several host factors. However, despite their critical role in disease and protection, the glycosylated variants of these two proteins and their biological importance have remained understudied. In this review, we seek to provide a comprehensive summary of the current knowledge on protein glycosylation in DENV, and its role in virus biogenesis, host cell receptor interaction and disease pathogenesis. © 2017 Yap, Nguyen-Khuong, Rudd and Alonso.
Source Title: Frontiers in Microbiology
URI: https://scholarbank.nus.edu.sg/handle/10635/173780
ISSN: 1664302X
DOI: 10.3389/fmicb.2017.01415
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