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Title: Repeatability and reproducibility of retinal neuronal and axonal measures on spectral-domain optical coherence tomography in patients with cognitive impairment
Authors: Loh, E.H.-T
Ong, Y.-T
Venketasubramanian, N 
Hilal, S 
Thet, N
Wong, T.Y 
Chen, C.P.L 
Cheung, C.Y.-L
Issue Date: 2017
Citation: Loh, E.H.-T, Ong, Y.-T, Venketasubramanian, N, Hilal, S, Thet, N, Wong, T.Y, Chen, C.P.L, Cheung, C.Y.-L (2017). Repeatability and reproducibility of retinal neuronal and axonal measures on spectral-domain optical coherence tomography in patients with cognitive impairment. Frontiers in Neurology 8 (AUG) : 359. ScholarBank@NUS Repository.
Abstract: Background: With increasing interest in determining if measurement of retinal neuronal structure with spectral-domain optical coherence tomography (SD-OCT) is useful in accessing neurodegenerative process in cognitive decline and development of dementia, it is important to evaluate whether the SD-OCT measurements are repeatable and reproducible in these patients. Methods: This is a retrospective cohort study. Patients with Alzheimer's disease (AD) or mild cognitive impairment (MCI) with no change in global clinical dementia rating (CDR) score at 1-year follow-up were eligible to be included. Ganglion cell-inner plexiform layer (GC-IPL) and retinal nerve fiber layer (RNFL) parameters were measured with SD-OCT at baseline, 6-month, and 1-year follow-up visits. At baseline, SD-OCT scans were repeated to access intra-visit repeatability of the SD-OCT measurement. SD-OCT measurement over three visits was used to access inter-visit reproducibility. We calculated intraclass correlation coefficients (ICC) and coefficients of variation (CoVs). Results: We included 32 patients with stable AD and 29 patients with stable MCI in the final analysis. For GC-IPL measures, the average intra-visit ICC was 0.969 (range: 0.948-0.985), and CoV was 1.81% (range: 1.14-2.40); while the average inter-visit ICC was 0.968 (0.941-0.985), and CoV was 1.91% (range: 1.24-2.32). The average ICC and CoV of intra-visit RNFL measured were 0.965 (range: 0.937-0.986) and 2.32% (range: 1.34-2.90%), respectively. The average ICC and CoV of inter-visit RNFL measures were 0.927 (range: 0.845-0.961) and 3.83% (range: 2.71-5.25%), respectively. Conclusion: Both GC-IPL and RNFL measurements had good intra-visit repeatability and inter-visit reproducibility over 1 year in elderly patients with no decline in cognitive function, suggesting that SD-OCT is a reliable tool to assess neurodegenerative process over time. © 2017 Loh, Ong, Venketasubramanian, Hilal, Thet, Wong, Chen and Cheung.
Source Title: Frontiers in Neurology
ISSN: 16642295
DOI: 10.3389/fneur.2017.00359
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