Please use this identifier to cite or link to this item: https://doi.org/10.1186/s12986-017-0216-0
Title: Sex-specific association between fibroblast growth factor 21 and type 2 diabetes: A nested case-control study in Singapore Chinese men and women
Authors: Wang, Y 
Koh, W.-P 
Yuan, J.-M
Pan, A
Keywords: fibroblast growth factor 21
adult
aged
Article
case control study
Chinese
cohort analysis
controlled study
female
human
incidence
major clinical study
male
non insulin dependent diabetes mellitus
prospective study
protein blood level
risk factor
sex difference
Singapore
Issue Date: 2017
Citation: Wang, Y, Koh, W.-P, Yuan, J.-M, Pan, A (2017). Sex-specific association between fibroblast growth factor 21 and type 2 diabetes: A nested case-control study in Singapore Chinese men and women. Nutrition and Metabolism 14 (1) : 216. ScholarBank@NUS Repository. https://doi.org/10.1186/s12986-017-0216-0
Abstract: Background: Fibroblast growth factor 21 (FGF-21) is mainly secreted by liver and has been reported to be involved in the pathogenesis of type 2 diabetes. Some prospective studies have shown a positive association between FGF-21 and diabetes risk. However, no study has examined whether the association differed by sex, which has been reported between FGF-21 and atherosclerosis. Therefore, we prospectively evaluated the sex-specific association between FGF-21 and diabetes in a Chinese population. Methods: Serum FGF-21 concentration was measured in a case-control study comprising of 251 incident diabetes cases and 251 age-sex-matched controls nested within a prospective population-based cohort, the Singapore Chinese Health Study. At blood collection between 1999 and 2004, participants were free of diagnosed diabetes, cardiovascular disease, and cancer. Incident self-reported diabetes cases were identified at follow-up II interview (2006-2010). Odds ratio (OR) and 95% confidence interval (CI) were calculated using multivariable logistic regression models. Results: After adjustment for risk biomarkers of diabetes including lipids, liver enzymes and inflammatory marker, the OR of type 2 diabetes with per one unit increment in log FGF-21 concentration was 1.16 (95% CI 0.90-1.50). Significant interaction was found with sex (P-interaction = 0.029): The OR (95% CI) was 1.50 (1.00-2.25) in women and 0.89 (0.52-1.53) in men. Conclusions: Higher serum FGF-21 level was associated with an increased risk of diabetes in Chinese women but not in men. The sex difference in the association between FGF-21 and diabetes risk deserves further investigation and replication in other populations. © 2017 The Author(s).
Source Title: Nutrition and Metabolism
URI: https://scholarbank.nus.edu.sg/handle/10635/173770
ISSN: 17437075
DOI: 10.1186/s12986-017-0216-0
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