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Title: Sex-specific association between fibroblast growth factor 21 and type 2 diabetes: A nested case-control study in Singapore Chinese men and women
Authors: Wang, Y 
Koh, W.-P 
Yuan, J.-M
Pan, A
Keywords: fibroblast growth factor 21
case control study
cohort analysis
controlled study
major clinical study
non insulin dependent diabetes mellitus
prospective study
protein blood level
risk factor
sex difference
Issue Date: 2017
Citation: Wang, Y, Koh, W.-P, Yuan, J.-M, Pan, A (2017). Sex-specific association between fibroblast growth factor 21 and type 2 diabetes: A nested case-control study in Singapore Chinese men and women. Nutrition and Metabolism 14 (1) : 216. ScholarBank@NUS Repository.
Abstract: Background: Fibroblast growth factor 21 (FGF-21) is mainly secreted by liver and has been reported to be involved in the pathogenesis of type 2 diabetes. Some prospective studies have shown a positive association between FGF-21 and diabetes risk. However, no study has examined whether the association differed by sex, which has been reported between FGF-21 and atherosclerosis. Therefore, we prospectively evaluated the sex-specific association between FGF-21 and diabetes in a Chinese population. Methods: Serum FGF-21 concentration was measured in a case-control study comprising of 251 incident diabetes cases and 251 age-sex-matched controls nested within a prospective population-based cohort, the Singapore Chinese Health Study. At blood collection between 1999 and 2004, participants were free of diagnosed diabetes, cardiovascular disease, and cancer. Incident self-reported diabetes cases were identified at follow-up II interview (2006-2010). Odds ratio (OR) and 95% confidence interval (CI) were calculated using multivariable logistic regression models. Results: After adjustment for risk biomarkers of diabetes including lipids, liver enzymes and inflammatory marker, the OR of type 2 diabetes with per one unit increment in log FGF-21 concentration was 1.16 (95% CI 0.90-1.50). Significant interaction was found with sex (P-interaction = 0.029): The OR (95% CI) was 1.50 (1.00-2.25) in women and 0.89 (0.52-1.53) in men. Conclusions: Higher serum FGF-21 level was associated with an increased risk of diabetes in Chinese women but not in men. The sex difference in the association between FGF-21 and diabetes risk deserves further investigation and replication in other populations. © 2017 The Author(s).
Source Title: Nutrition and Metabolism
ISSN: 17437075
DOI: 10.1186/s12986-017-0216-0
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