Please use this identifier to cite or link to this item:
https://doi.org/10.3389/fimmu.2018.00261
DC Field | Value | |
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dc.title | Calcineurin B in CD4+ T Cells prevents autoimmune colitis by negatively regulating the JAK/STAT pathway | |
dc.contributor.author | Mencarelli, A | |
dc.contributor.author | Vacca, M | |
dc.contributor.author | Khameneh, H.J | |
dc.contributor.author | Acerbi, E | |
dc.contributor.author | Tay, A | |
dc.contributor.author | Zolezzi, F | |
dc.contributor.author | Poidinger, M | |
dc.contributor.author | Mortellaro, A | |
dc.date.accessioned | 2020-09-01T00:45:11Z | |
dc.date.available | 2020-09-01T00:45:11Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Mencarelli, A, Vacca, M, Khameneh, H.J, Acerbi, E, Tay, A, Zolezzi, F, Poidinger, M, Mortellaro, A (2018). Calcineurin B in CD4+ T Cells prevents autoimmune colitis by negatively regulating the JAK/STAT pathway. Frontiers in Immunology 9 (FEB) : 261. ScholarBank@NUS Repository. https://doi.org/10.3389/fimmu.2018.00261 | |
dc.identifier.issn | 16643224 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/173738 | |
dc.description.abstract | Calcineurin (Cn) is a protein phosphatase that regulates the activation of the nuclear factor of activated T-cells (NFAT) family of transcription factors, which are key regulators of T-cell development and function. Here, we generated a conditional Cnb1 mouse model in which Cnb1 was specifically deleted in CD4+ T cells (Cnb1CD4 mice) to delineate the role of the Cn-NFAT pathway in immune homeostasis of the intestine. The Cnb1CD4 mice developed severe, spontaneous colitis characterized at the molecular level by an increased T helper-1-cell response but an unaltered regulatory T-cell compartment. Antibiotic treatment ameliorated the intestinal inflammation observed in Cnb1CD4 mice, suggesting that the microbiota contributes to the onset of colitis. CD4+ T cells isolated from Cnb1CD4 mice produced high levels of IFN? due to increased activation of the JAK2/STAT4 pathway induced by IL-12. Our data highlight that Cn signaling in CD4+ T cells is critical for intestinal immune homeostasis in part by inhibiting IL-12 responsiveness of CD4+ T cells. © 2018 Mencarelli, Vacca, Khameneh, Acerbi, Tay, Zolezzi, Poidinger and Mortellaro. | |
dc.source | Unpaywall 20200831 | |
dc.subject | ampicillin | |
dc.subject | calcineurin | |
dc.subject | gamma interferon | |
dc.subject | Hermes antigen | |
dc.subject | interleukin 12 | |
dc.subject | ionomycin | |
dc.subject | metronidazole | |
dc.subject | streptomycin | |
dc.subject | vancomycin | |
dc.subject | animal cell | |
dc.subject | animal experiment | |
dc.subject | animal model | |
dc.subject | apoptosis | |
dc.subject | Article | |
dc.subject | autoimmune disease | |
dc.subject | body weight gain | |
dc.subject | bone marrow cell | |
dc.subject | CD4+ T lymphocyte | |
dc.subject | cell activation | |
dc.subject | cell differentiation | |
dc.subject | cell infiltration | |
dc.subject | cell isolation | |
dc.subject | cell migration | |
dc.subject | cell proliferation | |
dc.subject | colitis | |
dc.subject | controlled study | |
dc.subject | cytokine production | |
dc.subject | disease predisposition | |
dc.subject | enteritis | |
dc.subject | enzyme linked immunosorbent assay | |
dc.subject | flow cytometry | |
dc.subject | gene expression | |
dc.subject | helper cell | |
dc.subject | histology | |
dc.subject | homeostasis | |
dc.subject | inflammatory bowel disease | |
dc.subject | intestine flora | |
dc.subject | JAK-STAT signaling | |
dc.subject | lamina propria | |
dc.subject | microarray analysis | |
dc.subject | mouse | |
dc.subject | nonhuman | |
dc.subject | regulatory T lymphocyte | |
dc.subject | scoring system | |
dc.subject | Th1 cell | |
dc.subject | Th17 cell | |
dc.subject | thymus | |
dc.type | Article | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.contributor.department | MICROBIOLOGY AND IMMUNOLOGY | |
dc.contributor.department | BIOLOGY (NU) | |
dc.description.doi | 10.3389/fimmu.2018.00261 | |
dc.description.sourcetitle | Frontiers in Immunology | |
dc.description.volume | 9 | |
dc.description.issue | FEB | |
dc.description.page | 261 | |
Appears in Collections: | Staff Publications Elements |
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