Please use this identifier to cite or link to this item: https://doi.org/10.1017/S0033291717003154
Title: Directional associations between memory impairment and depressive symptoms: data from a longitudinal sample and meta-analysis
Authors: YU JUNHONG 
Lim, Hui-Ying
FADZILLAH NUR D/O MOHAMED ABDULLAH 
CHAN HUI MINN 
RATHI MAHENDRAN 
ROGER HO CHUN MAN 
KUA EE HEOK 
POWER, MICHAEL JOHN 
Feng Lei 
Keywords: Social Sciences
Science & Technology
Life Sciences & Biomedicine
Psychology, Clinical
Psychiatry
Psychology
Aging
cross-lagged
depression
longitudinal
memory
MILD COGNITIVE IMPAIRMENT
LATE-LIFE DEPRESSION
OLDER-ADULTS
RISK-FACTORS
DEMENTIA
PREVALENCE
VITAMIN-B-12
PERFORMANCE
DISORDER
DECLINE
Issue Date: 1-Jul-2018
Publisher: CAMBRIDGE UNIV PRESS
Citation: YU JUNHONG, Lim, Hui-Ying, FADZILLAH NUR D/O MOHAMED ABDULLAH, CHAN HUI MINN, RATHI MAHENDRAN, ROGER HO CHUN MAN, KUA EE HEOK, POWER, MICHAEL JOHN, Feng Lei (2018-07-01). Directional associations between memory impairment and depressive symptoms: data from a longitudinal sample and meta-analysis. PSYCHOLOGICAL MEDICINE 48 (10) : 1664-1672. ScholarBank@NUS Repository. https://doi.org/10.1017/S0033291717003154
Abstract: Background: Previous cross-lagged studies on depression and memory impairment among the elderly have revealed conflicting findings relating to the direction of influence between depression and memory impairment. The current study aims to clarify this direction of influence by examining the cross-lagged relationships between memory impairment and depression in an Asian sample of elderly community dwellers, as well as synthesizing previous relevant cross-lagged findings via a meta-analysis. Methods: A total of 160 participants (Mage = 68.14, s.d. = 5.34) were assessed across two time points (average of 1.9 years apart) on measures of memory and depressive symptoms. The data were then fitted to a structural equation model to examine two cross-lagged effects (i.e. depressive symptoms→memory; memory→depressive symptoms). A total of 14 effect-sizes for each of the two cross-lagged directions were extracted from six studies (including the present; total N = 8324). These effects were then meta-analyzed using a three-level mixed effects model. Results: In the current sample, lower memory ability at baseline was associated with worse depressive symptoms levels at follow-up, after controlling for baseline depressive symptoms. However, the reverse effect was not significant; baseline depressive symptoms did not predict subsequent memory ability after controlling for baseline memory. The results of the meta-analysis revealed the same pattern of relationship between memory and depressive symptoms. Conclusions: These results provide robust evidence that the relationship between memory impairment and depressive symptoms is unidirectional; memory impairment predicts subsequent depressive symptoms but not vice-versa. The implications of these findings are discussed.
Source Title: PSYCHOLOGICAL MEDICINE
URI: https://scholarbank.nus.edu.sg/handle/10635/173635
ISSN: 0033-2917
1469-8978
DOI: 10.1017/S0033291717003154
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