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https://doi.org/10.1016/j.biomaterials.2011.11.033
Title: | Photodynamic inactivation of viruses using upconversion nanoparticles | Authors: | Lim, Meng Earn Lee, Yen-ling Zhang, Yong Chu, Justin Jang Hann |
Keywords: | Science & Technology Technology Engineering, Biomedical Materials Science, Biomaterials Engineering Materials Science Nanoparticle Upconversion Viral pathogen Photodynamic therapy DENGUE-2 VIRUS THERAPY PHOTOSENSITIZERS CANCER FLUORESCENCE CELLS |
Issue Date: | 1-Feb-2012 | Publisher: | ELSEVIER SCI LTD | Citation: | Lim, Meng Earn, Lee, Yen-ling, Zhang, Yong, Chu, Justin Jang Hann (2012-02-01). Photodynamic inactivation of viruses using upconversion nanoparticles. BIOMATERIALS 33 (6) : 1912-1920. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biomaterials.2011.11.033 | Abstract: | Photodynamic therapy (PDT) is a promising treatment modality that utilizes light of an appropriate wavelength to excite photosensitive materials called photosensitizers, which upon excitation, generate reactive oxygen species (ROS) that are cytocidal and virucidal. However, problems such as hydrophobicity of photosensitizers and limited tissue penetration ability of the current light sources impeded its promotion as a mainstay in medical technology. Here, by using near-infrared (NIR)-to-visible upconversion nanoparticles (UCNs), we demonstrate UCN-based photodynamic inactivation as a potential antiviral strategy. These UCNs are nanotransducers which not only act as carriers of photosensitizers but also active participants in PDT by transducing NIR radiation to visible emissions appropriate for excitation of the attached photosensitizers. The UCNs effectively reduced the infectious virus titers in vitro with no clear pathogenicity in murine model and increased target specificity to virus-infected cells. Hence, this is a promising antiviral approach with feasible applications in the treatments of virus-associated infections, lesions and cancers. © 2011 Elsevier Ltd. | Source Title: | BIOMATERIALS | URI: | https://scholarbank.nus.edu.sg/handle/10635/173295 | ISSN: | 01429612 18785905 |
DOI: | 10.1016/j.biomaterials.2011.11.033 |
Appears in Collections: | Staff Publications Elements |
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