Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.antiviral.2017.11.017
Title: An evaluation of Chloroquine as a broad-acting antiviral against Hand, Foot and Mouth Disease
Authors: Tan, Yong Wah
Yam, Wan Keat 
Sun, Jialei
Chu, Justin Jang Hann 
Keywords: Science & Technology
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Virology
Enterovirus
EV-A71
Chloroquine
HFMD
Antiviral
ENTEROVIRUS 71
CHINA
EPIDEMIOLOGY
CHILDREN
SINGAPORE
PROTEIN
MALARIA
Issue Date: 1-Jan-2018
Publisher: ELSEVIER SCIENCE BV
Citation: Tan, Yong Wah, Yam, Wan Keat, Sun, Jialei, Chu, Justin Jang Hann (2018-01-01). An evaluation of Chloroquine as a broad-acting antiviral against Hand, Foot and Mouth Disease. ANTIVIRAL RESEARCH 149 : 143-149. ScholarBank@NUS Repository. https://doi.org/10.1016/j.antiviral.2017.11.017
Abstract: © 2017 Elsevier B.V. A common childhood affliction of viral origin in young children and immunocompromised adults, the Hand, Foot and Mouth Disease (HFMD) has become a significant public health concern in the Asia-Pacific Region. Characterized by the appearance of vesiculopapular rashes on the hands, feet and mouth, the disease is generally mild and self-limiting. In a minority of cases, patients can develop neurological complications that could result in permanent morbidity or even fatality. In the absence of a specific antiviral for treatment, medical care is limited to supportive and symptomatic relief, presenting a need for more research into an effective antiviral to be used in the management of the disease. In this study, we evaluated the efficacy of chloroquine, a FDA-approved lysosomotropic agent, against several serotypes of HFMD-associated enteroviruses, including EV-A71, in reducing infectious virus production. We have also evaluated chloroquine in a murine model of EV-A71 infection to ascertain its antiviral efficacy in vivo. The results suggest that chloroquine could be a broad-acting antiviral effective against HFMD-associated enteroviruses.
Source Title: ANTIVIRAL RESEARCH
URI: https://scholarbank.nus.edu.sg/handle/10635/173279
ISSN: 01663542
18729096
DOI: 10.1016/j.antiviral.2017.11.017
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
14.pdfAccepted version914.53 kBAdobe PDF

OPEN

Post-printView/Download

SCOPUSTM   
Citations

32
checked on May 3, 2021

Page view(s)

93
checked on Apr 30, 2021

Download(s)

2
checked on Apr 30, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.