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|Title:||ENGINEERING MESENCHYMAL STEM CELL PARACRINE SIGNALING FOR CARTILAGE REGENERATION||Authors:||NURUL DINAH BINTE KADIR||ORCID iD:||orcid.org/0000-0002-0474-4088||Keywords:||Mesenchymal stem cells (MSCs), Electrospun fibrous scaffolds, MSC secretome, Paracrine functions, Chondrocytes, Cartilage repair||Issue Date:||8-Jan-2020||Citation:||NURUL DINAH BINTE KADIR (2020-01-08). ENGINEERING MESENCHYMAL STEM CELL PARACRINE SIGNALING FOR CARTILAGE REGENERATION. ScholarBank@NUS Repository.||Abstract:||Secretome profiles of MSCs are reflective of their local microenvironments and able to create an impact on the surrounding cells, eliciting regenerative responses that open up the opportunity of exploiting MSCs towards a cell-free therapy for cartilage repair. The conventional method of culturing MSCs on a tissue culture plate might not have provided the physiological microenvironment for optimum secretome production. This study explored the potential of surface topographies in influencing the MSC secretome production and the possibility of these factors in enhancing the functionality of MSCs and chondrocytes for cartilage repair. Conditioned media generated from MSCs cultured in fibrous scaffolds have improved secretome yield and profile that promote migration, proliferation, MSC chondrogenesis, as well as mitigate inflammation and protect chondrocytes from apoptosis. Thus, the production of MSC secretome from fibrous scaffolds could be a more efficient approach of cell-free therapy in clinical application for articular cartilage regeneration.||URI:||https://scholarbank.nus.edu.sg/handle/10635/173118|
|Appears in Collections:||Ph.D Theses (Open)|
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