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|Title:||A study of quality and safety of herbal medicine: adulteration and herb-drug interactions||Authors:||HOU PEILING||Keywords:||quality control, herbal medicine, adulteration, herb-drug interaction, Ligusticum chuanxiong||Issue Date:||28-Aug-2009||Citation:||HOU PEILING (2009-08-28). A study of quality and safety of herbal medicine: adulteration and herb-drug interactions. ScholarBank@NUS Repository.||Abstract:||With the popular use of herbal medicines, the key issues such as quality and safety are investigated in this study for the rational assessment of them. In the assessment of quality, analytical methods for the detection and structural identification of a novel adulterant (hydroxyacetildenafil) were successfully established. In addition, HPLC, LC-MS/MS, high resolution LC-MS methods for rapid profiling of components in a model Chinese herb, Ligusticum chuanxiong have been successfully developed. For the assessment safety, the ex vivo and in vivo methods to assess the potential herb-drug interactions between L. chuanxiong and aspirin were developed and applied. 14-day pre-treatment with L. chuanxiong (10 g herb?kg-1?d-1) significantly increased CYP 2D activity ex vivo in SD rat hepatic microsomes, while the induction effect was not seen under in vivo condition. In a following study, L. chuanxiong pre-treatment did not affect the antiplatelet effect of aspirin in rats nor did it change the pharmacokinetics of aspirin and salicylic acid after a single intravenous administration of aspirin. However, the bioavailability (F) of aspirin was reduced by 54.6% in L. chuanxiong pre-treatment group after a single intraperitoneal administration of aspirin, suggesting a potential pharmacokinetic herb-drug interaction between L. chuanxiong and aspirin. This work successfully provides support and experimental platform for the quality and safety evaluations of herbal medicines.||URI:||http://scholarbank.nus.edu.sg/handle/10635/17222|
|Appears in Collections:||Ph.D Theses (Open)|
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