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https://doi.org/10.1021/acsami.5b03766
Title: | Biocompatible Green and Red Fluorescent Organic Dots with Remarkably Large Two-Photon Action Cross Sections for Targeted Cellular Imaging and Real-Time Intravital Blood Vascular Visualization | Authors: | Xiang, Jiayun Cai, Xiaolei Lou, Xiaoding Feng, Guangxue Min, Xuehong Luo, Wenwen He, Bairong Goh, Chi Ching Ng, Lai Guan Zhou, Jian Zhao, Zujin Liu, Bin Tang, Ben Zhong |
Keywords: | Science & Technology Technology Nanoscience & Nanotechnology Materials Science, Multidisciplinary Science & Technology - Other Topics Materials Science organic dots two-photon absorption two-photon fluorescence bioimaging tetraphenylethene AGGREGATION-INDUCED EMISSION CONJUGATED POLYMER NANOPARTICLES LONG-TERM SILICA NANOPARTICLES QUANTUM DOTS STEM-CELLS AIE DOTS TETRAPHENYLETHENE PROBES CYTOTOXICITY |
Issue Date: | 15-Jul-2015 | Publisher: | AMER CHEMICAL SOC | Citation: | Xiang, Jiayun, Cai, Xiaolei, Lou, Xiaoding, Feng, Guangxue, Min, Xuehong, Luo, Wenwen, He, Bairong, Goh, Chi Ching, Ng, Lai Guan, Zhou, Jian, Zhao, Zujin, Liu, Bin, Tang, Ben Zhong (2015-07-15). Biocompatible Green and Red Fluorescent Organic Dots with Remarkably Large Two-Photon Action Cross Sections for Targeted Cellular Imaging and Real-Time Intravital Blood Vascular Visualization. ACS APPLIED MATERIALS & INTERFACES 7 (27) : 14965-14974. ScholarBank@NUS Repository. https://doi.org/10.1021/acsami.5b03766 | Abstract: | © 2015 American Chemical Society. Fluorescent organic dots are emerging as promising bioimaging reagents because of their high brightness, good photostability, excellent biocompatibility, and facile surface functionalization. Organic dots with large two-photon absorption (TPA) cross sections are highly desired for two-photon fluorescence microscopy. In this work, we report two biocompatible and photostable organic dots fabricated by encapsulating tetraphenylethene derivatives within DSPE-PEG matrix. The two organic dots show absorption maxima at 425 and 483 nm and emit green and red fluorescence at 560 and 645 nm, with high fluorescence quantum yields of 64% and 22%, respectively. Both organic dots exhibit excellent TPA property in the range of 800-960 nm, affording upon excitation at 820 nm remarkably large TPA cross sections of 1.2 × 106 and 2.5 × 106 GM on the basis of dot concentration. The bare fluorophores and their organic dots are biocompatible and have been used to stain living cells for one- and two-photon fluorescence bioimagings. The cRGD-modified organic dots can selectively target integrin α |
Source Title: | ACS APPLIED MATERIALS & INTERFACES | URI: | https://scholarbank.nus.edu.sg/handle/10635/171899 | ISSN: | 19448244 19448252 |
DOI: | 10.1021/acsami.5b03766 |
Appears in Collections: | Staff Publications Elements |
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Biocompatible Green and Red Fluorescent Organic Dots with Remarkably Large Two-Photon Action Cross Sections for Targeted Cellular Imaging and Real-Time Intravital Blood Vascular Visualization.pdf | Accepted version | 775.15 kB | Adobe PDF | OPEN | Post-print | View/Download |
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