Please use this identifier to cite or link to this item: https://doi.org/10.1021/acsnano.9b01665
Title: Cancer-Cell-Activated Photodynamic Therapy Assisted by Cu(II)-Based Metal-Organic Framework
Authors: Wang, Yuanbo
Wu, Wenbo
LIU JINGJING 
Manghnani, Purnima Naresh
Hu, Fang
Ma, Dou
TEH CATHLEEN
Wang, Bo
LIU BIN 
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Chemistry
Science & Technology - Other Topics
Materials Science
activatable photodynamic therapy
photosensitizers
aggregation-induced emission
metal-organic frameworks
glutathione
AGGREGATION-INDUCED EMISSION
HIGHLY EFFICIENT
DRUG-DELIVERY
PHOTOSENSITIZERS
GLUTATHIONE
NANOPARTICLES
NANOMEDICINE
POLYMER
MODELS
STATE
Issue Date: 1-Jun-2019
Publisher: American Chemical Society
Citation: Wang, Yuanbo, Wu, Wenbo, LIU JINGJING, Manghnani, Purnima Naresh, Hu, Fang, Ma, Dou, TEH CATHLEEN, Wang, Bo, LIU BIN (2019-06-01). Cancer-Cell-Activated Photodynamic Therapy Assisted by Cu(II)-Based Metal-Organic Framework. ACS Nano 13 (6) : 6879-6890. ScholarBank@NUS Repository. https://doi.org/10.1021/acsnano.9b01665
Abstract: Activation of photosensitizers (PSs) in targeted lesion and minimization of reactive oxygen species (ROS) depletion by endogenous antioxidants constitute promising approaches to perform highly effective image-guided photodynamic therapy (PDT) with minimal non-specific phototoxicity. Traditional strategies to fabricate controllable PS platforms rely on molecular design, which requires specific modification of each PS before PDT. Therefore, construction of a general tumor-responsive PDT platform with minimum ROS loss from endogenous antioxidant, typically glutathione (GSH), is highly desirable. Herein, MOF-199, a Cu(II) carboxylate-based metal-organic framework (MOF), is selected to serve as an inert carrier to load PSs with prohibited photosensitization during delivery. After cellular uptake, Cu (II) in the MOFs effectively scavenges endogenous GSH, concomitantly induces decomposition of MOF-199 to release the encapsulated PSs, and recovers their ROS generation. In vitro and in vivo experiments demonstrate highly effective cancer cell ablation and anticancer PDT with diminished normal cell phototoxicity. This strategy is generally applicable to PSs with both aggregation-induced emission and aggregation-caused quenching to implement activatable and enhanced image-guided PDT.
Source Title: ACS Nano
URI: https://scholarbank.nus.edu.sg/handle/10635/170708
ISBN: 1936-086X
ISSN: 1936-0851
DOI: 10.1021/acsnano.9b01665
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