Please use this identifier to cite or link to this item: https://doi.org/10.1021/acsnano.9b01665
DC FieldValue
dc.titleCancer-Cell-Activated Photodynamic Therapy Assisted by Cu(II)-Based Metal-Organic Framework
dc.contributor.authorWang, Yuanbo
dc.contributor.authorWu, Wenbo
dc.contributor.authorLIU JINGJING
dc.contributor.authorManghnani, Purnima Naresh
dc.contributor.authorHu, Fang
dc.contributor.authorMa, Dou
dc.contributor.authorTEH CATHLEEN
dc.contributor.authorWang, Bo
dc.contributor.authorLIU BIN
dc.date.accessioned2020-06-25T01:39:30Z
dc.date.available2020-06-25T01:39:30Z
dc.date.issued2019-06-01
dc.identifier.citationWang, Yuanbo, Wu, Wenbo, LIU JINGJING, Manghnani, Purnima Naresh, Hu, Fang, Ma, Dou, TEH CATHLEEN, Wang, Bo, LIU BIN (2019-06-01). Cancer-Cell-Activated Photodynamic Therapy Assisted by Cu(II)-Based Metal-Organic Framework. ACS Nano 13 (6) : 6879-6890. ScholarBank@NUS Repository. https://doi.org/10.1021/acsnano.9b01665
dc.identifier.isbn1936-086X
dc.identifier.issn1936-0851
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/170708
dc.description.abstractActivation of photosensitizers (PSs) in targeted lesion and minimization of reactive oxygen species (ROS) depletion by endogenous antioxidants constitute promising approaches to perform highly effective image-guided photodynamic therapy (PDT) with minimal non-specific phototoxicity. Traditional strategies to fabricate controllable PS platforms rely on molecular design, which requires specific modification of each PS before PDT. Therefore, construction of a general tumor-responsive PDT platform with minimum ROS loss from endogenous antioxidant, typically glutathione (GSH), is highly desirable. Herein, MOF-199, a Cu(II) carboxylate-based metal-organic framework (MOF), is selected to serve as an inert carrier to load PSs with prohibited photosensitization during delivery. After cellular uptake, Cu (II) in the MOFs effectively scavenges endogenous GSH, concomitantly induces decomposition of MOF-199 to release the encapsulated PSs, and recovers their ROS generation. In vitro and in vivo experiments demonstrate highly effective cancer cell ablation and anticancer PDT with diminished normal cell phototoxicity. This strategy is generally applicable to PSs with both aggregation-induced emission and aggregation-caused quenching to implement activatable and enhanced image-guided PDT.
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.sourceElements
dc.subjectScience & Technology
dc.subjectPhysical Sciences
dc.subjectTechnology
dc.subjectChemistry, Multidisciplinary
dc.subjectChemistry, Physical
dc.subjectNanoscience & Nanotechnology
dc.subjectMaterials Science, Multidisciplinary
dc.subjectChemistry
dc.subjectScience & Technology - Other Topics
dc.subjectMaterials Science
dc.subjectactivatable photodynamic therapy
dc.subjectphotosensitizers
dc.subjectaggregation-induced emission
dc.subjectmetal-organic frameworks
dc.subjectglutathione
dc.subjectAGGREGATION-INDUCED EMISSION
dc.subjectHIGHLY EFFICIENT
dc.subjectDRUG-DELIVERY
dc.subjectPHOTOSENSITIZERS
dc.subjectGLUTATHIONE
dc.subjectNANOPARTICLES
dc.subjectNANOMEDICINE
dc.subjectPOLYMER
dc.subjectMODELS
dc.subjectSTATE
dc.typeArticle
dc.date.updated2020-06-11T07:36:39Z
dc.contributor.departmentDEPT OF CHEMICAL & BIOMOLECULAR ENGG
dc.description.doi10.1021/acsnano.9b01665
dc.description.sourcetitleACS Nano
dc.description.volume13
dc.description.issue6
dc.description.page6879-6890
dc.published.statePublished
Appears in Collections:Staff Publications
Elements

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
acsnano.9b01665.pdfAccepted version1.73 MBAdobe PDF

OPEN

Post-printView/Download

SCOPUSTM   
Citations

73
checked on Sep 21, 2021

Page view(s)

132
checked on Sep 23, 2021

Download(s)

7
checked on Sep 23, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.