Please use this identifier to cite or link to this item: https://doi.org/10.1039/c8mh00946e
Title: Identifying glioblastoma margins using dual-targeted organic nanoparticles for efficient in vivo fluorescence image-guided photothermal therapy
Authors: CAI XIAOLEI 
Aishwarya Bandla 
CHAN KIM CHUAN 
GAYATHIRI MAGARAJAH 
LIAO LUN-DE 
Teh, Daniel Boon Loong
Kennedy, Brian K
Thakor, Nitish V
LIU BIN 
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Materials Science, Multidisciplinary
Chemistry
Materials Science
BLOOD-BRAIN-BARRIER
MULTIFORME
SURVIVAL
TEMOZOLOMIDE
GRAPHENE
Issue Date: 1-Feb-2019
Publisher: Royal Society of Chemistry (RSC)
Citation: CAI XIAOLEI, Aishwarya Bandla, CHAN KIM CHUAN, GAYATHIRI MAGARAJAH, LIAO LUN-DE, Teh, Daniel Boon Loong, Kennedy, Brian K, Thakor, Nitish V, LIU BIN (2019-02-01). Identifying glioblastoma margins using dual-targeted organic nanoparticles for efficient in vivo fluorescence image-guided photothermal therapy. Materials Horizons 6 (2) : 311-317. ScholarBank@NUS Repository. https://doi.org/10.1039/c8mh00946e
Abstract: Current therapeutics for glioblastoma multiforme (GBM) treatment are unsatisfactory due to their limited ability to control the progression from tumour margins. In this work, organic nanoparticles (NPs) are synthesized by co-encapsulating a fluorogen with aggregation-induced emission to generate a bright red emission for imaging and a semiconducting polymer to offer NIR absorption for photothermal therapy. The NPs are further modified with different ratios of two targeting ligands, folate and cRGD peptide. The best ratio that performs specific and efficient GBM targeting is screened out through in vitro and ex vivo fluorescence imaging analysis. The NPs with an FA to cRGD ratio of 25 : 75 exhibit superior ability to target GBM cells in vitro and also show efficient accumulation at the GBM margin and in the tumour interior after in vivo administration. The progression of GBM can be greatly suppressed through photothermal therapy, which provides a simple but promising strategy for GBM treatment.
Source Title: Materials Horizons
URI: https://scholarbank.nus.edu.sg/handle/10635/170701
ISSN: 2051-6347
2051-6355
DOI: 10.1039/c8mh00946e
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
MH-CXL.pdfAccepted version524.2 kBAdobe PDF

OPEN

Post-printView/Download

SCOPUSTM   
Citations

32
checked on Oct 20, 2021

Page view(s)

148
checked on Oct 14, 2021

Download(s)

2
checked on Oct 14, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.