Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep14179
Title: Activity of andrographolide against chikungunya virus infection
Authors: Wintachai, P
PARVEEN KAUR 
LEE CHING HUA 
Ramphan, S
Kuadkitkan, A
Wikan, N
Ubol, S
Roytrakul, S
CHU JANG HANN 
Smith, Duncan R 
Keywords: Andrographis
Animals
Antiviral Agents
Cell Line
Cell Survival
Chikungunya Fever
Chikungunya virus
Cricetinae
Diterpenes
Gene Dosage
Gene Expression Regulation, Viral
Humans
Microbial Sensitivity Tests
Plant Extracts
RNA, Viral
Viral Plaque Assay
Virus Replication
Issue Date: 18-Sep-2015
Publisher: Springer Science and Business Media LLC
Citation: Wintachai, P, PARVEEN KAUR, LEE CHING HUA, Ramphan, S, Kuadkitkan, A, Wikan, N, Ubol, S, Roytrakul, S, CHU JANG HANN, Smith, Duncan R (2015-09-18). Activity of andrographolide against chikungunya virus infection. Scientific Reports 5 (1) : 14179-. ScholarBank@NUS Repository. https://doi.org/10.1038/srep14179
Abstract: © 2015, Nature Publishing Group. All rights reserved. Chikungunya virus (CHIKV) is a re-emerging mosquito-borne alphavirus that has recently engendered large epidemics around the world. There is no specific antiviral for treatment of patients infected with CHIKV, and development of compounds with significant anti-CHIKV activity that can be further developed to a practical therapy is urgently required. Andrographolide is derived from Andrographis paniculata, a herb traditionally used to treat a number of conditions including infections. This study sought to determine the potential of andrographolide as an inhibitor of CHIKV infection. Andrographolide showed good inhibition of CHIKV infection and reduced virus production by approximately 3log10 with a 50% effective concentration (EC50) of 77 μM without cytotoxicity. Time-of-addition and RNA transfection studies showed that andrographolide affected CHIKV replication and the activity of andrographolide was shown to be cell type independent. This study suggests that andrographolide has the potential to be developed further as an anti-CHIKV therapeutic agent.
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/170688
ISSN: 2045-2322
DOI: 10.1038/srep14179
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