Please use this identifier to cite or link to this item: https://doi.org/10.1002/adfm.202002546
Title: NIR-II Light Activated Photosensitizer with Aggregation-Induced Emission for Precise and Efficient Two-Photon Photodynamic Cancer Cell Ablation
Authors: Wang, Shaowei 
Chen, Huan 
Liu, Jie 
Chen, Chengjian 
Liu, Bin 
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Physics, Applied
Physics, Condensed Matter
Chemistry
Science & Technology - Other Topics
Materials Science
Physics
aggregation-induced emission
deep penetration
NIR-II
photosensitizer
two-photon photodynamic therapy
UP-CONVERSION NANOPARTICLES
THERAPY
ABSORPTION
AUTOPHAGY
TISSUE
Issue Date: 5-Jun-2020
Publisher: WILEY-V C H VERLAG GMBH
Citation: Wang, Shaowei, Chen, Huan, Liu, Jie, Chen, Chengjian, Liu, Bin (2020-06-05). NIR-II Light Activated Photosensitizer with Aggregation-Induced Emission for Precise and Efficient Two-Photon Photodynamic Cancer Cell Ablation. ADVANCED FUNCTIONAL MATERIALS. ScholarBank@NUS Repository. https://doi.org/10.1002/adfm.202002546
Abstract: © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Near infrared (NIR) light excitable photosensitizers are highly desirable for photodynamic therapy with deep penetration. Herein, a NIR-II light (1200 nm) activated photosensitizer TQ-BTPE is designed with aggregation-induced singlet oxygen (1O2) generation for two-photon photodynamic cancer cell ablation. TQ-BTPE shows good two-photon absorption and bright aggregation-induced NIR-I emission upon NIR-II laser excitation. The 1O2 produced by TQ-BTPE in an aqueous medium is much more efficient than that of commercial photosensitizer Ce6 under white light irradiation. Upon NIR-II excitation, the two-photon photosensitization of TQ-BTPE is sevenfold higher than that of Ce6. The TQ-BTPE molecules internalized by HeLa cells are mostly located in lysosomes as small aggregate dots with homogeneous distribution inside the cells, which favors efficient photodynamic cell ablation. The two-photon photosensitization of TQ-BTPE upon NIR-I and NIR-II excitation shows higher 1O2 generation efficiency than under NIR-I excitation owing to the larger two-photon absorption cross section at 920 nm. However, NIR-II light exhibits better biological tissue penetration capability after passing through a fresh pork tissue, which facilitates stronger two-photon photosensitization and better cancer cell ablation performance. This work highlights the promise of NIR-II light excitable photosensitizers for deep-tissue photodynamic therapy.
Source Title: ADVANCED FUNCTIONAL MATERIALS
URI: https://scholarbank.nus.edu.sg/handle/10635/170648
ISSN: 1616-301X
1616-3028
DOI: 10.1002/adfm.202002546
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