Please use this identifier to cite or link to this item: https://doi.org/10.1002/adfm.202002546
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dc.titleNIR-II Light Activated Photosensitizer with Aggregation-Induced Emission for Precise and Efficient Two-Photon Photodynamic Cancer Cell Ablation
dc.contributor.authorWang, Shaowei
dc.contributor.authorChen, Huan
dc.contributor.authorLiu, Jie
dc.contributor.authorChen, Chengjian
dc.contributor.authorLiu, Bin
dc.date.accessioned2020-06-22T08:04:59Z
dc.date.available2020-06-22T08:04:59Z
dc.date.issued2020-06-05
dc.identifier.citationWang, Shaowei, Chen, Huan, Liu, Jie, Chen, Chengjian, Liu, Bin (2020-06-05). NIR-II Light Activated Photosensitizer with Aggregation-Induced Emission for Precise and Efficient Two-Photon Photodynamic Cancer Cell Ablation. ADVANCED FUNCTIONAL MATERIALS. ScholarBank@NUS Repository. https://doi.org/10.1002/adfm.202002546
dc.identifier.issn1616-301X
dc.identifier.issn1616-3028
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/170648
dc.description.abstract© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Near infrared (NIR) light excitable photosensitizers are highly desirable for photodynamic therapy with deep penetration. Herein, a NIR-II light (1200 nm) activated photosensitizer TQ-BTPE is designed with aggregation-induced singlet oxygen (1O2) generation for two-photon photodynamic cancer cell ablation. TQ-BTPE shows good two-photon absorption and bright aggregation-induced NIR-I emission upon NIR-II laser excitation. The 1O2 produced by TQ-BTPE in an aqueous medium is much more efficient than that of commercial photosensitizer Ce6 under white light irradiation. Upon NIR-II excitation, the two-photon photosensitization of TQ-BTPE is sevenfold higher than that of Ce6. The TQ-BTPE molecules internalized by HeLa cells are mostly located in lysosomes as small aggregate dots with homogeneous distribution inside the cells, which favors efficient photodynamic cell ablation. The two-photon photosensitization of TQ-BTPE upon NIR-I and NIR-II excitation shows higher 1O2 generation efficiency than under NIR-I excitation owing to the larger two-photon absorption cross section at 920 nm. However, NIR-II light exhibits better biological tissue penetration capability after passing through a fresh pork tissue, which facilitates stronger two-photon photosensitization and better cancer cell ablation performance. This work highlights the promise of NIR-II light excitable photosensitizers for deep-tissue photodynamic therapy.
dc.language.isoen
dc.publisherWILEY-V C H VERLAG GMBH
dc.sourceElements
dc.subjectScience & Technology
dc.subjectPhysical Sciences
dc.subjectTechnology
dc.subjectChemistry, Multidisciplinary
dc.subjectChemistry, Physical
dc.subjectNanoscience & Nanotechnology
dc.subjectMaterials Science, Multidisciplinary
dc.subjectPhysics, Applied
dc.subjectPhysics, Condensed Matter
dc.subjectChemistry
dc.subjectScience & Technology - Other Topics
dc.subjectMaterials Science
dc.subjectPhysics
dc.subjectaggregation-induced emission
dc.subjectdeep penetration
dc.subjectNIR-II
dc.subjectphotosensitizer
dc.subjecttwo-photon photodynamic therapy
dc.subjectUP-CONVERSION NANOPARTICLES
dc.subjectTHERAPY
dc.subjectABSORPTION
dc.subjectAUTOPHAGY
dc.subjectTISSUE
dc.typeArticle
dc.date.updated2020-06-20T10:34:07Z
dc.contributor.departmentDEPT OF CHEMICAL & BIOMOLECULAR ENGG
dc.description.doi10.1002/adfm.202002546
dc.description.sourcetitleADVANCED FUNCTIONAL MATERIALS
dc.published.statePublished
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