Please use this identifier to cite or link to this item:
https://doi.org/10.1002/adfm.202002546
DC Field | Value | |
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dc.title | NIR-II Light Activated Photosensitizer with Aggregation-Induced Emission for Precise and Efficient Two-Photon Photodynamic Cancer Cell Ablation | |
dc.contributor.author | Wang, Shaowei | |
dc.contributor.author | Chen, Huan | |
dc.contributor.author | Liu, Jie | |
dc.contributor.author | Chen, Chengjian | |
dc.contributor.author | Liu, Bin | |
dc.date.accessioned | 2020-06-22T08:04:59Z | |
dc.date.available | 2020-06-22T08:04:59Z | |
dc.date.issued | 2020-06-05 | |
dc.identifier.citation | Wang, Shaowei, Chen, Huan, Liu, Jie, Chen, Chengjian, Liu, Bin (2020-06-05). NIR-II Light Activated Photosensitizer with Aggregation-Induced Emission for Precise and Efficient Two-Photon Photodynamic Cancer Cell Ablation. ADVANCED FUNCTIONAL MATERIALS. ScholarBank@NUS Repository. https://doi.org/10.1002/adfm.202002546 | |
dc.identifier.issn | 1616-301X | |
dc.identifier.issn | 1616-3028 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/170648 | |
dc.description.abstract | © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Near infrared (NIR) light excitable photosensitizers are highly desirable for photodynamic therapy with deep penetration. Herein, a NIR-II light (1200 nm) activated photosensitizer TQ-BTPE is designed with aggregation-induced singlet oxygen (1O2) generation for two-photon photodynamic cancer cell ablation. TQ-BTPE shows good two-photon absorption and bright aggregation-induced NIR-I emission upon NIR-II laser excitation. The 1O2 produced by TQ-BTPE in an aqueous medium is much more efficient than that of commercial photosensitizer Ce6 under white light irradiation. Upon NIR-II excitation, the two-photon photosensitization of TQ-BTPE is sevenfold higher than that of Ce6. The TQ-BTPE molecules internalized by HeLa cells are mostly located in lysosomes as small aggregate dots with homogeneous distribution inside the cells, which favors efficient photodynamic cell ablation. The two-photon photosensitization of TQ-BTPE upon NIR-I and NIR-II excitation shows higher 1O2 generation efficiency than under NIR-I excitation owing to the larger two-photon absorption cross section at 920 nm. However, NIR-II light exhibits better biological tissue penetration capability after passing through a fresh pork tissue, which facilitates stronger two-photon photosensitization and better cancer cell ablation performance. This work highlights the promise of NIR-II light excitable photosensitizers for deep-tissue photodynamic therapy. | |
dc.language.iso | en | |
dc.publisher | WILEY-V C H VERLAG GMBH | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Physical Sciences | |
dc.subject | Technology | |
dc.subject | Chemistry, Multidisciplinary | |
dc.subject | Chemistry, Physical | |
dc.subject | Nanoscience & Nanotechnology | |
dc.subject | Materials Science, Multidisciplinary | |
dc.subject | Physics, Applied | |
dc.subject | Physics, Condensed Matter | |
dc.subject | Chemistry | |
dc.subject | Science & Technology - Other Topics | |
dc.subject | Materials Science | |
dc.subject | Physics | |
dc.subject | aggregation-induced emission | |
dc.subject | deep penetration | |
dc.subject | NIR-II | |
dc.subject | photosensitizer | |
dc.subject | two-photon photodynamic therapy | |
dc.subject | UP-CONVERSION NANOPARTICLES | |
dc.subject | THERAPY | |
dc.subject | ABSORPTION | |
dc.subject | AUTOPHAGY | |
dc.subject | TISSUE | |
dc.type | Article | |
dc.date.updated | 2020-06-20T10:34:07Z | |
dc.contributor.department | CHEMICAL & BIOMOLECULAR ENGINEERING | |
dc.description.doi | 10.1002/adfm.202002546 | |
dc.description.sourcetitle | ADVANCED FUNCTIONAL MATERIALS | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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File | Description | Size | Format | Access Settings | Version | |
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Manuscript_clean copy.pdf | Accepted version | 2.78 MB | Adobe PDF | OPEN | Post-print | View/Download |
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