Please use this identifier to cite or link to this item: https://doi.org/10.1038/sdata.2018.231
Title: Data Descriptor: Lipid profiling of C. elegans strains administered pro-longevity drugs and drug combinations
Authors: Admasu, Tesfahun Dessale
Batchu, Krishna Chaithanya 
Ng, Li Fang 
Cazenave-Gassiot, Amaury 
Wenk, Markus R 
Gruber, Jan 
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
LIFE-SPAN EXTENSION
METFORMIN
BRAIN
MICE
Issue Date: 23-Oct-2018
Publisher: NATURE PUBLISHING GROUP
Citation: Admasu, Tesfahun Dessale, Batchu, Krishna Chaithanya, Ng, Li Fang, Cazenave-Gassiot, Amaury, Wenk, Markus R, Gruber, Jan (2018-10-23). Data Descriptor: Lipid profiling of C. elegans strains administered pro-longevity drugs and drug combinations. SCIENTIFIC DATA 5 (1). ScholarBank@NUS Repository. https://doi.org/10.1038/sdata.2018.231
Abstract: © The Author(s) 2018. We report the effect of four lifespan modifying drugs and of synergistic combinations of these drugs on lipid profile in Caenorhabditis elegans. We employ ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS) to compare the abundance of lipid species in treated and control animals. Adult nematodes were treated with rapamycin, rifampicin, psora-4 and allantoin and combinations of these compounds and the resulting change in lipid profiles, specifically in those of triacylglycerol (TAG), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) were determined. We quantified changes resulting from treatment with the drug combinations relative to untreated controls and relative to animals treated with each constituent single drugs. We further determined the dependence of changes in lipid profiles on genes known to affect lipid metabolism using strains carrying mutations in these pathways. In particular, we determined lipid profiles in a genetic model of caloric restriction (eat-2), a strain lacking homolog of TGFβ (daf-7) and in a strain lacking the SREBP/sbp-1 transcription factor.
Source Title: SCIENTIFIC DATA
URI: https://scholarbank.nus.edu.sg/handle/10635/170470
ISSN: 20524463
DOI: 10.1038/sdata.2018.231
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