Please use this identifier to cite or link to this item:
Title: Nanofibrous Surface Modification of Ultra-Thin PCL Membrane for Cardiovascular Tissue Engineering Application
Keywords: PCL, cardiovascular tissue engineering, surface modification, nanofiber, electrospinning, cell attachment
Issue Date: 2-Nov-2006
Citation: CHEN FENGHAO (2006-11-02). Nanofibrous Surface Modification of Ultra-Thin PCL Membrane for Cardiovascular Tissue Engineering Application. ScholarBank@NUS Repository.
Abstract: Poly (e-caprolactone) (PCL) is a popularly used biomaterial for various tissue engineering applications, but this setback of unfavorable cell affinity hinders its application for cardiovascular tissue engineering (CTVE) where a strong attachment between cells and scaffold is required. This thesis reports on a novel surface modification by extracellular matrix (ECM) mimic electrospun nanofibers. In this study, PCL membrane scaffold was coated with PCL nanofibers via electrospinning process and subjected to sodium hydroxide treatment The results revealed a uniform stable nanofibrous topology with increased roughness and surface area. Capillary effects were induced, causing almost zero water contact angle. Favorable cell proliferation, morphology and dramatically enhanced cell attachment were also observed on the hybrid scaffold.This study indicated that the nanofibrous surface modification remarkably enhanced the cell affinity to PCL membrane scaffold. We are optimistic that this technique has posed the way for future applications in CTVE.
Appears in Collections:Master's Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
ChenFenghao MSc GPBE 2006.pdf4.17 MBAdobe PDF



Page view(s)

checked on Apr 12, 2019


checked on Apr 12, 2019

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.