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Title: Manipulation of polymorphonuclear neutrophils respiratory burst
Keywords: Neutrophils, Respiratory Burst, Superoxide, Hydrogen Peroxide, Photoactivated MC540, enzyme activity
Issue Date: 15-Jun-2005
Citation: NG SIEW BOON (2005-06-15). Manipulation of polymorphonuclear neutrophils respiratory burst. ScholarBank@NUS Repository.
Abstract: Polymorphonuclear neutrophils are an important part of the immune system where they function to get rid of microorganisms through oxidative killing and release of microcidal products. Inappropriate activity of the oxidative killing pathway may lead to the development of diseases which may be fatal to the host. Thus a compound which can manipulate the activity of the oxidative pathway would be useful in the treatment of such diseases.Photoactivated MC540 and one of its purified compounds C1 was found to be able to change levels of oxidative products in tumor cell lines and thus were used to investigate their effects on the respiratory burst of neutrophils. We found evidence the ability of C1 to decrease the amount of respiratory burst in neutrophils and that it decreases the activity of NADPH oxidase involved in the respiratory burst pathway. No effect was observed in other microcidal functions of neutrophils by C1.
Appears in Collections:Master's Theses (Open)

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