Please use this identifier to cite or link to this item:
https://doi.org/10.1002/smll.201602807
DC Field | Value | |
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dc.title | Multifunctional Conjugated Polymer Nanoparticles for Image-Guided Photodynamic and Photothermal Therapy | |
dc.contributor.author | Feng, Guangxue | |
dc.contributor.author | Fang, Yuan | |
dc.contributor.author | Liu, Jie | |
dc.contributor.author | Geng, Junlong | |
dc.contributor.author | Ding, Dan | |
dc.contributor.author | Liu, Bin | |
dc.date.accessioned | 2020-06-17T03:48:00Z | |
dc.date.available | 2020-06-17T03:48:00Z | |
dc.date.issued | 2017-01-18 | |
dc.identifier.citation | Feng, Guangxue, Fang, Yuan, Liu, Jie, Geng, Junlong, Ding, Dan, Liu, Bin (2017-01-18). Multifunctional Conjugated Polymer Nanoparticles for Image-Guided Photodynamic and Photothermal Therapy. SMALL 13 (3). ScholarBank@NUS Repository. https://doi.org/10.1002/smll.201602807 | |
dc.identifier.issn | 16136810 | |
dc.identifier.issn | 16136829 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/169951 | |
dc.description.abstract | © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim A multifunctional theranostic platform based on conjugated polymer nanoparticles (CPNs) with tumor targeting, fluorescence detection, photodynamic therapy (PDT), and photothermal therapy (PTT) is developed for effective cancer imaging and therapy. Two conjugated polymers, poly[9,9-bis(2-(2-(2-methoxyethoxy)ethoxy)-ethyl)fluorenyldivinylene]-alt-4,7-(2,1,3-benzothiadiazole) with bright red emission and photosensitizing ability and poly[(4,4,9,9-tetrakis(4-(octyloxy)phenyl)-4,9-dihydro-s-indacenol-dithiophene-2,7-diyl)-alt-co-4,9-bis(thiophen-2-yl)-6,7-bis(4-(hexyloxy)phenyl)-thiadiazolo-quinoxaline] with strong near-infrared absorption and excellent photothermal conversion ability are co-loaded into one single CPN via encapsulation approach using lipid-polyethylene glycol as the matrix. The obtained co-loaded CPNs show sizes of around 30 nm with a high singlet oxygen quantum yield of 60.4% and an effective photothermal conversion efficiency of 47.6%. The CPN surface is further decorated with anti-HER2 affibody, which bestows the resultant anti-HER2-CPNs superior selectivity toward tumor cells with HER2 overexpression both in vitro and in vivo. Under light irradiation, the PDT and PTT show synergistic therapeutic efficacy, which provides new opportunities for the development of multifunctional biocompatible organic materials in cancer therapy. | |
dc.language.iso | en | |
dc.publisher | Wiley-VCH Verlag GmbH | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Physical Sciences | |
dc.subject | Technology | |
dc.subject | Chemistry, Multidisciplinary | |
dc.subject | Chemistry, Physical | |
dc.subject | Nanoscience & Nanotechnology | |
dc.subject | Materials Science, Multidisciplinary | |
dc.subject | Physics, Applied | |
dc.subject | Physics, Condensed Matter | |
dc.subject | Chemistry | |
dc.subject | Science & Technology - Other Topics | |
dc.subject | Materials Science | |
dc.subject | Physics | |
dc.subject | IN-VIVO | |
dc.subject | SINGLET OXYGEN | |
dc.subject | DRUG-DELIVERY | |
dc.subject | CANCER-CELLS | |
dc.subject | PHOTO-IMMUNOTHERAPY | |
dc.subject | GOLD NANOPARTICLES | |
dc.subject | AFFIBODY MOLECULE | |
dc.subject | PHOTOIMMUNOTHERAPY | |
dc.subject | DOTS | |
dc.subject | NANOCRYSTALS | |
dc.type | Article | |
dc.date.updated | 2020-06-10T10:56:49Z | |
dc.contributor.department | CHEMICAL & BIOMOLECULAR ENGINEERING | |
dc.description.doi | 10.1002/smll.201602807 | |
dc.description.sourcetitle | SMALL | |
dc.description.volume | 13 | |
dc.description.issue | 3 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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File | Description | Size | Format | Access Settings | Version | |
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Feng-small PDT PTT.pdf | Accepted version | 3.42 MB | Adobe PDF | OPEN | Post-print | View/Download |
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