Please use this identifier to cite or link to this item: https://doi.org/10.1039/c6sc04384d
Title: Long wavelength excitable near-infrared fluorescent nanoparticles with aggregation-induced emission characteristics for image-guided tumor resection
Authors: Liu, Jie 
Chen, Chao
Ji, Shenglu
Liu, Qian
Ding, Dan 
Zhao, Dan 
LIU BIN 
Keywords: Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
INTRAMOLECULAR CHARGE-TRANSFER
ORGANIC NANOPARTICLES
CELL TRACKING
BIOCOMPATIBLE NANOPARTICLES
INDOCYANINE GREEN
CANCER-SURGERY
AIE DOTS
BRIGHT
BIOPROBES
PROBES
Issue Date: 1-Apr-2017
Publisher: ROYAL SOCIETY OF CHEMISTRY
Citation: Liu, Jie, Chen, Chao, Ji, Shenglu, Liu, Qian, Ding, Dan, Zhao, Dan, LIU BIN (2017-04-01). Long wavelength excitable near-infrared fluorescent nanoparticles with aggregation-induced emission characteristics for image-guided tumor resection. CHEMICAL SCIENCE 8 (4) : 2782-2789. ScholarBank@NUS Repository. https://doi.org/10.1039/c6sc04384d
Abstract: © The Royal Society of Chemistry. Near infrared (NIR) fluorescence imaging (700-900 nm) is a promising technology in preclinical and clinical tumor diagnosis and therapy. The availability of excellent NIR fluorescent contrast agents is still the main barrier to implementing this technology. Herein, we report the design and synthesis of two series of NIR fluorescent molecules with long wavelength excitation and aggregation-induced emission (AIE) characteristics by fine-tuning their molecular structures and substituents. Further self-assembly between an amphiphilic block co-polymer and the obtained AIE molecules leads to AIE nanoparticles (AIE NPs), which have absorption maxima at 635 nm and emission maxima between 800 and 815 nm with quantum yields of up to 4.8% in aggregated states. In vitro and in vivo toxicity results demonstrate that the synthesized AIE NPs are biocompatible. Finally, the synthesized AIE NPs have been successfully used for image-guided tumor resection with a high tumor-to-normal tissue signal ratio of 7.2.
Source Title: CHEMICAL SCIENCE
URI: https://scholarbank.nus.edu.sg/handle/10635/169935
ISSN: 20416520
20416539
DOI: 10.1039/c6sc04384d
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