Please use this identifier to cite or link to this item: https://doi.org/10.1021/acs.chemmater.9b01642
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dc.titleEncapsulation and Protection of Ultrathin Two-Dimensional Porous Organic Nanosheets within Biocompatible Metal-Organic Frameworks for Live-Cell Imaging
dc.contributor.authorDong, Jinqiao
dc.contributor.authorQiao, Zhiwei
dc.contributor.authorPan, Yutong
dc.contributor.authorPeh, Shing Bo
dc.contributor.authorYuan, Yi Di
dc.contributor.authorWang, Yuxiang
dc.contributor.authorZhai, Linzhi
dc.contributor.authorYuan, Hongye
dc.contributor.authorCheng, Youdong
dc.contributor.authorLiang, Hong
dc.contributor.authorLiu, Bin
dc.contributor.authorZhao, Dan
dc.date.accessioned2020-06-15T03:05:55Z
dc.date.available2020-06-15T03:05:55Z
dc.date.issued2019-07-09
dc.identifier.citationDong, Jinqiao, Qiao, Zhiwei, Pan, Yutong, Peh, Shing Bo, Yuan, Yi Di, Wang, Yuxiang, Zhai, Linzhi, Yuan, Hongye, Cheng, Youdong, Liang, Hong, Liu, Bin, Zhao, Dan (2019-07-09). Encapsulation and Protection of Ultrathin Two-Dimensional Porous Organic Nanosheets within Biocompatible Metal-Organic Frameworks for Live-Cell Imaging. CHEMISTRY OF MATERIALS 31 (13) : 4897-4912. ScholarBank@NUS Repository. https://doi.org/10.1021/acs.chemmater.9b01642
dc.identifier.issn08974756
dc.identifier.issn15205002
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/169761
dc.description.abstract© 2019 American Chemical Society. Despite the rapid development of ultrathin two-dimensional (2D) organic nanosheets, it still remains a challenge to stabilize them and prevent restacking so that they could be used in aqueous environments for biological applications such as live-cell bioimaging. Herein, we report an effective approach to stabilize and protect ultrathin 2D porous organic nanosheets (PONs) by encapsulating them with biocompatible zeolitic imidazolate framework-8 (ZIF-8) for in vitro live-cell imaging. We rationally design and synthesize few-layered 2D PONs named NUS 27-29 containing flexible tetraphenylethylene units as aggregation-induced emission (AIE) molecular rotors. The micrometer-sized freestanding 2D nanosheets of NUS 27-29 with thicknesses of 2-5 nm can be easily obtained by exfoliation from their bulk powders. We demonstrate that these 2D nanosheets can be armored by ZIF-8 crystals grown in situ for inhibition of restacking. Importantly, we find that the dynamics of the AIE molecular rotors of NUS 27-29 can be restricted by noncovalent interactions between the 2D nanosheets and ZIF-8 armor, as proved through experimental studies and theoretical simulations. As a result, the integration of these 2D nanosheets in ZIF-8 leads to highly stable, porous, and fluorescent composites. We further demonstrate that these composites can be employed as biological fluorescent probes for in vitro live-cell imaging. Our strategy shows the first example of transporting hydrophobic 2D organic nanosheets into live cancer cells by encapsulating within biocompatible MOFs, which should facilitate the further development of ultrathin 2D nanomaterials for various biological applications.
dc.language.isoen
dc.publisherAMERICAN CHEMICAL SOCIETY
dc.sourceElements
dc.subjectScience & Technology
dc.subjectPhysical Sciences
dc.subjectTechnology
dc.subjectChemistry, Physical
dc.subjectMaterials Science, Multidisciplinary
dc.subjectChemistry
dc.subjectMaterials Science
dc.subjectAGGREGATION-INDUCED EMISSION
dc.subjectMOLECULAR ROTORS
dc.subjectDRIVEN
dc.typeArticle
dc.date.updated2020-06-09T04:54:32Z
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.doi10.1021/acs.chemmater.9b01642
dc.description.sourcetitleCHEMISTRY OF MATERIALS
dc.description.volume31
dc.description.issue13
dc.description.page4897-4912
dc.published.statePublished
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