Please use this identifier to cite or link to this item: https://doi.org/10.1002/smll.201803325
Title: Simultaneous Increase in Brightness and Singlet Oxygen Generation of an Organic Photosensitizer by Nanocrystallization
Authors: Fateminia, SM Ali
Kacenauskaite, Laura
Zhang, Chong-Jing 
Kenry, Suqian Ma
Manghnani, Purnima N
Chen, Junsheng
Xu, Shidang 
Hu, Fang 
Xu, Bin
Laursen, Bo W
Liu, Bin 
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Physics, Applied
Physics, Condensed Matter
Chemistry
Science & Technology - Other Topics
Materials Science
Physics
aggregation-induced emission
amorphous nanoaggregates
nanocrystals
photodynamic therapy
photosensitizers
AGGREGATION-INDUCED EMISSION
PHOTODYNAMIC THERAPY
NANOPARTICLES
ABLATION
PROBE
Issue Date: 27-Dec-2018
Publisher: WILEY-V C H VERLAG GMBH
Citation: Fateminia, SM Ali, Kacenauskaite, Laura, Zhang, Chong-Jing, Kenry, Suqian Ma, Manghnani, Purnima N, Chen, Junsheng, Xu, Shidang, Hu, Fang, Xu, Bin, Laursen, Bo W, Liu, Bin (2018-12-27). Simultaneous Increase in Brightness and Singlet Oxygen Generation of an Organic Photosensitizer by Nanocrystallization. SMALL 14 (52). ScholarBank@NUS Repository. https://doi.org/10.1002/smll.201803325
Abstract: © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Efficient organic photosensitizers are attractive for cancer cell ablation in photodynamic therapy. Bright fluorescent photosensitizers are highly desirable for simultaneous imaging and therapy. However, due to fundamental competition between emission and singlet oxygen generation, design attempts to increase singlet oxygen generation almost always leads to the loss of fluorescence. Herein, it is shown for the first time that nanocrystallization enables a simultaneous and significant increase in the brightness and singlet oxygen generation of an organic photosensitizer. Spectroscopic studies show simultaneous enhancement in the visible light absorption and fluorescence after nanocrystallization. The enhanced absorption of visible light in nanocrystals is found to translate directly to the enhanced singlet oxygen production, which shows a higher ability to kill HeLa cells as compared to their amorphous counterpart.
Source Title: SMALL
URI: https://scholarbank.nus.edu.sg/handle/10635/169756
ISSN: 16136810
16136829
DOI: 10.1002/smll.201803325
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