Please use this identifier to cite or link to this item: https://doi.org/10.1021/acs.analchem.8b00547
Title: Dual-Responsive Metabolic Precursor and Light-Up AlEgen for Cancer Cell Bio-orthogonal Labeling and Precise Ablation
Authors: Hu, Fang
YUAN YOUYONG 
Wu, Wenbo
MAO DUO 
LIU BIN 
Keywords: Science & Technology
Physical Sciences
Chemistry, Analytical
Chemistry
AGGREGATION-INDUCED EMISSION
CLICK CHEMISTRY
PROBES
Issue Date: 5-Jun-2018
Publisher: American Chemical Society
Citation: Hu, Fang, YUAN YOUYONG, Wu, Wenbo, MAO DUO, LIU BIN (2018-06-05). Dual-Responsive Metabolic Precursor and Light-Up AlEgen for Cancer Cell Bio-orthogonal Labeling and Precise Ablation. Analytical Chemistry 90 (11) : 6718-6724. ScholarBank@NUS Repository. https://doi.org/10.1021/acs.analchem.8b00547
Abstract: Metabolic glycoengineering of unnatural glycans with bio-orthogonal chemical groups and a subsequent click reaction with fluorescent probes have been widely used in monitoring various bioprocesses. Herein, we developed a dual-responsive metabolic precursor that could specifically generate unnatural glycans with azide groups on the membrane of targeted cancer cells with high selectivity. Moreover, a water-soluble fluorescent light-up probe with aggregation-induced emission (AIE) was synthesized, which turned its fluorescence on upon a click reaction with azide groups on the cancer cell surface, enabling special cancer cell imaging with low background signal. Furthermore, the probe can generate 1O2 upon light irradiation, fulfilling its dual role as an imaging and therapeutic agent for cancer cells. Therefore, the concepts of the cancer-cell-specific metabolic precursor cRGD-S-Ac3ManNAz and the AIE light-up probe are promising in bio-orthogonal labeling and cancer-specific imaging and therapy.
Source Title: Analytical Chemistry
URI: https://scholarbank.nus.edu.sg/handle/10635/169671
ISSN: 0003-2700
1520-6882
DOI: 10.1021/acs.analchem.8b00547
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