Please use this identifier to cite or link to this item: https://doi.org/10.1002/smll.201601630
Title: Organic Nanoparticles with Aggregation-Induced Emission for Bone Marrow Stromal Cell Tracking in a Rat PTI Model
Authors: CAI XIAOLEI 
Zhang Chongjing 
Lim, Frances Ting Wei
Chan, Su Jing
Bandla, Aishwarya
Chuan, Chan Kim
Hu, Fang
XU SHIDANG 
Thakor, Nitish V
LIAO LUN-DE 
LIU BIN 
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Physics, Applied
Physics, Condensed Matter
Chemistry
Science & Technology - Other Topics
Materials Science
Physics
MESENCHYMAL STEM-CELLS
ACUTE ISCHEMIC-STROKE
IN-VIVO
SECONDARY PREVENTION
THERAPEUTIC BENEFIT
CANCER-CELLS
DOTS
VITRO
INFARCTION
BIOPROBE
Issue Date: 21-Dec-2016
Publisher: Wiley-VCH Verlag
Citation: CAI XIAOLEI, Zhang Chongjing, Lim, Frances Ting Wei, Chan, Su Jing, Bandla, Aishwarya, Chuan, Chan Kim, Hu, Fang, XU SHIDANG, Thakor, Nitish V, LIAO LUN-DE, LIU BIN (2016-12-21). Organic Nanoparticles with Aggregation-Induced Emission for Bone Marrow Stromal Cell Tracking in a Rat PTI Model. Small 12 (47) : 6576-6585. ScholarBank@NUS Repository. https://doi.org/10.1002/smll.201601630
Abstract: Stem-cell based therapy is an emerging therapeutic approach for ischemic stroke treatment. Bone marrow stromal cells (BMSCs) are in common use as a cell source for stem cell therapy and show promising therapeutic outcomes for stroke treatment. One challenge is to develop a reliable tracking strategy to monitor the fate of BMSCs and assess their therapeutic effects in order to improve the success rate of such treatment. Herein, TPEEP, a fluorogen with aggregation-induced emission characteristics and near-infrared emission are designed and synthesized and further fabricated into organic nanoparticles (NPs). The obtained NPs show high fluorescence quantum yield, low cytotoxicity with good physical and photostability, which display excellent tracking performance of BMSCs in vitro and in vivo. Using a rat photothrombotic ischemia model as an example, the NP-labeled BMSCs are able to migrate to the stroke lesion site to yield bright red fluorescence. Immunofluorescence staining shows that the NP labeling does not affect the normal function of BMSCs, proving their good biocompatibility in vivo. These merits make TPEEP NP a potential cell tracker to evaluate the fate of BMSCs in cell therapy.
Source Title: Small
URI: https://scholarbank.nus.edu.sg/handle/10635/169666
ISSN: 1613-6810
1613-6829
DOI: 10.1002/smll.201601630
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