Please use this identifier to cite or link to this item: https://doi.org/10.1002/adfm.201501081
Title: Conjugated Polymer Nanodots as Ultrastable Long-Term Trackers to Understand Mesenchymal Stem Cell Therapy in Skin Regeneration
Authors: Jin, Guorui
MAO DUO 
Cai, Pingqiang
Liu, Rongrong
Tomczak, Nikodem
LIU JIE 
Chen, Xiaodong
Kong, Deling
Ding, Dan
LIU BIN 
Li, Kai
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Physics, Applied
Physics, Condensed Matter
Chemistry
Science & Technology - Other Topics
Materials Science
Physics
IN-VIVO
QUANTUM DOTS
TISSUE REGENERATION
PARACRINE FACTORS
TRACKING
NANOPARTICLES
FLUORESCENCE
MEDICINE
DIFFERENTIATION
DISEASE
Issue Date: 15-Jul-2015
Publisher: Wiley-VCH Verlag
Citation: Jin, Guorui, MAO DUO, Cai, Pingqiang, Liu, Rongrong, Tomczak, Nikodem, LIU JIE, Chen, Xiaodong, Kong, Deling, Ding, Dan, LIU BIN, Li, Kai (2015-07-15). Conjugated Polymer Nanodots as Ultrastable Long-Term Trackers to Understand Mesenchymal Stem Cell Therapy in Skin Regeneration. Advanced Functional Materials 25 (27) : 4263-4273. ScholarBank@NUS Repository. https://doi.org/10.1002/adfm.201501081
Abstract: Stem cell-based therapies hold great promise in providing desirable solutions for diseases that cannot be effectively cured by conventional therapies. To maximize the therapeutic potentials, advanced cell tracking probes are essential to understand the fate of transplanted stem cells without impairing their properties. Herein, conjugated polymer (CP) nanodots are introduced as noninvasive fluorescent trackers with high brightness and low cytotoxicity for tracking of mesenchymal stem cells (MSCs) to reveal their in vivo behaviors. As compared to the most widely used commercial quantum dot tracker, CP nanodots show significantly better long-term tracking ability without compromising the features of MSCs in terms of proliferation, migration, differentiation, and secretome. Fluorescence imaging of tissue sections from full-thickness skin wound-bearing mice transplanted with CP nanodot-labeled MSCs suggests that paracrine signaling of the MSCs residing in the regenerated dermis is the predominant contribution to promote skin regeneration, accompanied with a small fraction of endothelial differentiation. The promising results indicate that CP nanodots could be used as next generation of fluorescent trackers to reveal the currently ambiguous mechanisms in stem cell therapies through a facile and effective approach.
Source Title: Advanced Functional Materials
URI: https://scholarbank.nus.edu.sg/handle/10635/169664
ISSN: 1616-301X
1616-3028
DOI: 10.1002/adfm.201501081
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