Please use this identifier to cite or link to this item: https://doi.org/10.1002/adfm.202002431
Title: Metal-Organic Framework Assisted and Tumor Microenvironment Modulated Synergistic Image-Guided Photo-Chemo Therapy
Authors: Wang, Yuanbo
Wu, Wenbo
MAO DUO 
Teh, Cathleen
Wang, Bo
LIU BIN 
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Physics, Applied
Physics, Condensed Matter
Chemistry
Science & Technology - Other Topics
Materials Science
Physics
aggregation-induced emission
image-guided photo-chemo therapy
metal-organic frameworks
targeted drug release
tumor microenvironment regulation
AGGREGATION-INDUCED EMISSION
PRODRUG-CONSTRUCTED LIPOSOMES
PHOTODYNAMIC THERAPY
HIGHLY EFFICIENT
ZEBRAFISH MODELS
HYPOXIC TUMOR
CANCER
NANOPARTICLES
ANGIOGENESIS
METASTASIS
Issue Date: 25-May-2020
Publisher: Advanced Functional Materials
Citation: Wang, Yuanbo, Wu, Wenbo, MAO DUO, Teh, Cathleen, Wang, Bo, LIU BIN (2020-05-25). Metal-Organic Framework Assisted and Tumor Microenvironment Modulated Synergistic Image-Guided Photo-Chemo Therapy. Advanced Functional Materials. ScholarBank@NUS Repository. https://doi.org/10.1002/adfm.202002431
Abstract: The complex tumor microenvironment (TME) and nonspecific drug targeting limit the clinical efficacy of photodynamic therapy in combination with chemotherapy. Herein, a metal–organic framework (MOF) assisted strategy is reported that modulates TME by reducing tumor hypoxia and intracellular glutathione (GSH) and offers targeted delivery and controlled release of the trapped chemodrug. Platinum(IV)-diazido complex (Pt(IV)) is loaded inside a Cu(II) carboxylate-based MOF, MOF-199, and an aggregation-induced-emission photosensitizer, TBD, is conjugated to polyethylene glycol for encapsulating Pt(IV)-loaded MOF-199. Once the fabricated TBD-Pt(IV)@MOF-199 nanoparticles are internalized by cancer cells, MOF-199 consumes intracellular GSH and decomposes to fragments to release Pt(IV). Upon light irradiation, the released Pt(IV) generates O2 that relieves hypoxia and produces Pt(II)-based chemodrug inside cancer cells. Concomitantly, efficient reactive oxygen species generation and bright emission are afforded by TBD, resulting in synergistic image-guided photo-chemo therapy with enhanced efficacies and mitigated side effects.
Source Title: Advanced Functional Materials
URI: https://scholarbank.nus.edu.sg/handle/10635/169656
ISSN: 1616-301X
1616-3028
DOI: 10.1002/adfm.202002431
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