Please use this identifier to cite or link to this item: https://doi.org/10.1039/c5sc01733e
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dc.titleTuning the singlet-triplet energy gap: a unique approach to efficient photosensitizers with aggregation-induced emission (AIE) characteristics
dc.contributor.authorXU SHIDANG
dc.contributor.authorYUAN YOUYONG
dc.contributor.authorCAI XIAOLEI
dc.contributor.authorZhang Chongjing
dc.contributor.authorHu, Fang
dc.contributor.authorLIANG JING
dc.contributor.authorZhang, Guanxin
dc.contributor.authorZhang, Deqing
dc.contributor.authorLIU BIN
dc.date.accessioned2020-06-11T01:12:55Z
dc.date.available2020-06-11T01:12:55Z
dc.date.issued2015-01-01
dc.identifier.citationXU SHIDANG, YUAN YOUYONG, CAI XIAOLEI, Zhang Chongjing, Hu, Fang, LIANG JING, Zhang, Guanxin, Zhang, Deqing, LIU BIN (2015-01-01). Tuning the singlet-triplet energy gap: a unique approach to efficient photosensitizers with aggregation-induced emission (AIE) characteristics. Chemical Science 6 (10) : 5824-5830. ScholarBank@NUS Repository. https://doi.org/10.1039/c5sc01733e
dc.identifier.issn2041-6520
dc.identifier.issn2041-6539
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/169641
dc.description.abstractThe efficiency of the intersystem crossing process can be improved by reducing the energy gap between the singlet and triplet excited states (ΔEST), which offers the opportunity to improve the yield of the triplet excited state. Herein, we demonstrate that modulation of the excited states is also an effective strategy to regulate the singlet oxygen generation of photosensitizers. Based on our previous studies that photosensitizers with aggregation-induced emission characteristics (AIE) showed enhanced fluorescence and efficient singlet oxygen production in the aggregated state, a series of AIE fluorogens such as TPDC, TPPDC and PPDC were synthesized, which showed ΔEST values of 0.48, 0.35 and 0.27 eV, respectively. A detailed study revealed that PPDC exhibited the highest singlet oxygen efficiency (0.89) as nanoaggregates, while TPDC exhibited the lowest efficiency (0.28), inversely correlated with their ΔEST values. Due to their similar optical properties, TPDC and PPDC were further encapsulated into nanoparticles (NPs). Subsequent surface modification with cell penetrating peptide (TAT) yielded TAT-TPDC NPs and TAT-PPDC NPs. As a result of the stronger singlet oxygen generation, TAT-PPDC NPs showed enhanced cancer cell ablation as compared to TAT-TPDC NPs. Fine-tuning of the singlet-triplet energy gap is thus proven to be an effective new strategy to generate efficient photosensitizers for photodynamic therapy.
dc.language.isoen
dc.publisherRoyal Society of Chemistry (RSC)
dc.sourceElements
dc.subjectScience & Technology
dc.subjectPhysical Sciences
dc.subjectChemistry, Multidisciplinary
dc.subjectChemistry
dc.subjectACTIVATED DELAYED FLUORESCENCE
dc.subjectLIGHT-EMITTING-DIODES
dc.subjectPHOTODYNAMIC THERAPY
dc.subjectCANCER-CELLS
dc.subjectOXYGEN GENERATION
dc.subjectHIGHLY EFFICIENT
dc.subjectORGANIC DOTS
dc.subjectUP BIOPROBE
dc.subjectDERIVATIVES
dc.subjectFLUOROGEN
dc.typeArticle
dc.date.updated2020-06-10T08:01:27Z
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.doi10.1039/c5sc01733e
dc.description.sourcetitleChemical Science
dc.description.volume6
dc.description.issue10
dc.description.page5824-5830
dc.published.statePublished
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