Please use this identifier to cite or link to this item: https://doi.org/10.1021/acsnano.8b08398
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dc.titlePolymerization-Enhanced Two-Photon Photosensitization for Precise Photodynamic Therapy
dc.contributor.authorWang, Shaowei
dc.contributor.authorWu, Wenbo
dc.contributor.authorManghnani, Purnima
dc.contributor.authorXu, Shidang
dc.contributor.authorWang, Yuanbo
dc.contributor.authorGoh, Chi Ching
dc.contributor.authorNg, Lai Guan
dc.contributor.authorLiu, Bin
dc.date.accessioned2020-06-10T07:00:45Z
dc.date.available2020-06-10T07:00:45Z
dc.date.issued2019-03-01
dc.identifier.citationWang, Shaowei, Wu, Wenbo, Manghnani, Purnima, Xu, Shidang, Wang, Yuanbo, Goh, Chi Ching, Ng, Lai Guan, Liu, Bin (2019-03-01). Polymerization-Enhanced Two-Photon Photosensitization for Precise Photodynamic Therapy. ACS NANO 13 (3) : 3095-3105. ScholarBank@NUS Repository. https://doi.org/10.1021/acsnano.8b08398
dc.identifier.issn19360851
dc.identifier.issn1936086X
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/169617
dc.description.abstract© 2019 American Chemical Society. Two-photon excited photodynamic therapy (2PE-PDT) has attracted great attention in recent years due to its great potential for deep-tissue and highly spatiotemporally precise cancer therapy. Photosensitizers (PSs) with high singlet oxygen ( 1 O 2 ) generation efficiency and large two-photon absorption (2PA) cross-sections are highly desirable, but the availability of such PSs is limited by challenges in molecular design. In this work, we report that the polymerization of small-molecule PSs with aggregation-induced emission (AIE) could yield conjugated polymer PSs with good brightness, high 1 O 2 generation efficiency, and large 2PA cross-sections. A pair of conjugated polymer PSs were designed and synthesized, and the corresponding AIE PS dots were prepared by nanoprecipitation, which exhibited outstanding 2PE-PDT performance in in vitro cancer cell ablation and in vivo zebrafish liver tumor treatment. Our work highlights a strategy to design highly efficient PSs for 2PE-PDT.
dc.language.isoen
dc.publisherAMER CHEMICAL SOC
dc.sourceElements
dc.subjectScience & Technology
dc.subjectPhysical Sciences
dc.subjectTechnology
dc.subjectChemistry, Multidisciplinary
dc.subjectChemistry, Physical
dc.subjectNanoscience & Nanotechnology
dc.subjectMaterials Science, Multidisciplinary
dc.subjectChemistry
dc.subjectScience & Technology - Other Topics
dc.subjectMaterials Science
dc.subjectconjugated polymer
dc.subjectphotosensitizer
dc.subjecttwo-photon
dc.subjectphotodynamic therapy
dc.subjectaggregation-induced emission
dc.subjectAGGREGATION-INDUCED EMISSION
dc.subjectEFFICIENT PHOTOSENSITIZERS
dc.subjectSINGLET OXYGEN
dc.subjectNANOPARTICLES
dc.subjectABSORPTION
dc.subjectEXCITATION
dc.subjectPOLYMERS
dc.subjectCANCER
dc.subjectCELLS
dc.subjectSTATE
dc.typeArticle
dc.date.updated2020-06-10T06:18:04Z
dc.contributor.departmentDEPT OF CHEMICAL & BIOMOLECULAR ENGG
dc.description.doi10.1021/acsnano.8b08398
dc.description.sourcetitleACS NANO
dc.description.volume13
dc.description.issue3
dc.description.page3095-3105
dc.published.statePublished
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