Please use this identifier to cite or link to this item: https://doi.org/10.1021/acsnano.8b08398
Title: Polymerization-Enhanced Two-Photon Photosensitization for Precise Photodynamic Therapy
Authors: Wang, Shaowei 
Wu, Wenbo 
Manghnani, Purnima
Xu, Shidang
Wang, Yuanbo
Goh, Chi Ching
Ng, Lai Guan
Liu, Bin 
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Chemistry
Science & Technology - Other Topics
Materials Science
conjugated polymer
photosensitizer
two-photon
photodynamic therapy
aggregation-induced emission
AGGREGATION-INDUCED EMISSION
EFFICIENT PHOTOSENSITIZERS
SINGLET OXYGEN
NANOPARTICLES
ABSORPTION
EXCITATION
POLYMERS
CANCER
CELLS
STATE
Issue Date: 1-Mar-2019
Publisher: AMER CHEMICAL SOC
Citation: Wang, Shaowei, Wu, Wenbo, Manghnani, Purnima, Xu, Shidang, Wang, Yuanbo, Goh, Chi Ching, Ng, Lai Guan, Liu, Bin (2019-03-01). Polymerization-Enhanced Two-Photon Photosensitization for Precise Photodynamic Therapy. ACS NANO 13 (3) : 3095-3105. ScholarBank@NUS Repository. https://doi.org/10.1021/acsnano.8b08398
Abstract: © 2019 American Chemical Society. Two-photon excited photodynamic therapy (2PE-PDT) has attracted great attention in recent years due to its great potential for deep-tissue and highly spatiotemporally precise cancer therapy. Photosensitizers (PSs) with high singlet oxygen ( 1 O 2 ) generation efficiency and large two-photon absorption (2PA) cross-sections are highly desirable, but the availability of such PSs is limited by challenges in molecular design. In this work, we report that the polymerization of small-molecule PSs with aggregation-induced emission (AIE) could yield conjugated polymer PSs with good brightness, high 1 O 2 generation efficiency, and large 2PA cross-sections. A pair of conjugated polymer PSs were designed and synthesized, and the corresponding AIE PS dots were prepared by nanoprecipitation, which exhibited outstanding 2PE-PDT performance in in vitro cancer cell ablation and in vivo zebrafish liver tumor treatment. Our work highlights a strategy to design highly efficient PSs for 2PE-PDT.
Source Title: ACS NANO
URI: https://scholarbank.nus.edu.sg/handle/10635/169617
ISSN: 19360851
1936086X
DOI: 10.1021/acsnano.8b08398
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