Please use this identifier to cite or link to this item: https://doi.org/10.1093/aje/kwn367
Title: Retinal Microvascular Caliber and Chronic Kidney Disease in an Asian Population
Authors: Sabanayagam, Charumathi 
Shankar, Anoop 
Koh, David 
Chia, Kee Seng 
Saw, Seang Mei 
Lim, Su Chi
Tai, E Shyong
Wong, Tien Yin 
Keywords: Science & Technology
Life Sciences & Biomedicine
Public, Environmental & Occupational Health
albuminuria
arterioles
glomerular filtration rate
kidney diseases
retina
Singapore
CARDIOVASCULAR RISK-FACTORS
ELEVATED BLOOD-PRESSURE
CHRONIC-RENAL-FAILURE
BODY-MASS INDEX
ATHEROSCLEROSIS RISK
VESSEL DIAMETERS
DIABETIC-RETINOPATHY
VASCULAR CALIBER
OLDER PERSONS
ABNORMALITIES
Issue Date: 1-Mar-2009
Publisher: OXFORD UNIV PRESS INC
Citation: Sabanayagam, Charumathi, Shankar, Anoop, Koh, David, Chia, Kee Seng, Saw, Seang Mei, Lim, Su Chi, Tai, E Shyong, Wong, Tien Yin (2009-03-01). Retinal Microvascular Caliber and Chronic Kidney Disease in an Asian Population. AMERICAN JOURNAL OF EPIDEMIOLOGY 169 (5) : 625-632. ScholarBank@NUS Repository. https://doi.org/10.1093/aje/kwn367
Abstract: Retinal arteriolar narrowing is a marker of microvascular damage from elevated blood pressure. Between August 2004 and June 2006, the authors examined the association between retinal vascular diameter and chronic kidney disease in a population-based cohort of 3,280 community-dwelling adults of Malay ethnicity aged 40-80 years living in Singapore. Chronic kidney disease was defined as 1) an estimated glomerular filtration rate (eGFR) of <60 mL/minute/1.73 m 2 from serum creatinine or 2) the presence of micro/macroalbuminuria defined as urinary albumin:creatinine ratios of ≥17 mg/g for men and ≥25 mg/g for women. Retinal arteriolar and venular diameters were measured and summarized as central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE). Individuals with reduced CRAE were more likely to have chronic kidney disease than those with increased CRAE. After controlling for age, gender, education, smoking, diabetes, hypertension, body mass index, and total and high density lipoprotein cholesterol, the authors found the odds ratio comparing the smallest with the largest CRAE quartile to be 1.42 (95% confidence interval: 1.03, 1.96; Ptrend = 0.02) for eGFR of <60 mL/minute/1.73 m2 and 1.80 (95% confidence interval: 1.11, 2.91; Ptrend = 0.01) for micro/macroalbuminuria. Retinopathy was also found to be positively associated with both eGFR and micro/macroalbuminuria. Retinal venular diameter was not associated with chronic kidney disease. These data suggest that retinal arteriolar narrowing is associated with chronic kidney disease, independent of diabetes and hypertension. © The Author 2008. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved.
Source Title: AMERICAN JOURNAL OF EPIDEMIOLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/169604
ISSN: 00029262
14766256
DOI: 10.1093/aje/kwn367
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