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Title: Differential expression of cellular genes during a West Nile virus infection
Authors: KOH WEE LEE
Keywords: West Nile virus, microarrays, gene expression
Issue Date: 18-May-2005
Citation: KOH WEE LEE (2005-05-18). Differential expression of cellular genes during a West Nile virus infection. ScholarBank@NUS Repository.
Abstract: West Nile virus (WNV) is a mosquito-borne flavivirus and has the potential to cause fatal meningoencephalitis in infected victims. A screening of the global genomic expression was carried out, as mechanisms of WNV-host interactions are still not well understood. A comparison of the transcriptomic profiles were carried out on HeLa and A172 cells, and time course study was performed on A172 cells. A172 cells were found to be permissive to WNV infection. Four functional classes of genes belonging to cytoskeletal structure and functions, hexose metabolism, protein biosynthesis and RNA processing were found to be significantly differentially regulated between the two cell types. In the time sequence study in WNV-infected A172 cells, differentially expressed genes during the course of the West Nile infection were clustered into 6 groups based on their gene expression patterns.
Appears in Collections:Master's Theses (Open)

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