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Title: Neurite outgrowth inhibitors in axoglial communication at the node of ranvier
Authors: NIE DUYU
Keywords: node of Ranvier, axon-glia interaction, myelination, Nogo, oligodendrocyte-myelin glycoprotein (OMgp), TN-R
Issue Date: 1-Nov-2005
Citation: NIE DUYU (2005-11-01). Neurite outgrowth inhibitors in axoglial communication at the node of ranvier. ScholarBank@NUS Repository.
Abstract: How the organization of the nodes of Ranvier and abutting domains in myelinated axons is regulated by glial cells remains poorly understood. In this study, oligodendrocyte-myelin glycoprotein (OMgp) and Nogo-A are identified as clusters in the nodal and paranodal domains, respectively. In the CNS, OMgp is involved in a network of interactions with other nodal molecules, including Nav channel subunits and TN-R. In the transgenic mice, down-regulation of OMgp causes dis-organization of nodal structure and decreased expression of Nav channel I? subunit. In vitro, OMgp protein has no effects on Nav channel distribution and sodium currents. Paranodal Nogo-A interacts with Caspr/paranodin via the Nogo-66. In animal models such as the experimental autoimmune encephalomyelitis (EAE) rats, the ceramide galactosyltransferase (CGT) and myelin basic protein (MBP) deficient mice, disruption of Nogo-A-Caspr interaction leads to misplacement of Kv1 channels. The results have demonstrated that some a??inhibitorya?? glial molecules undertake specific roles in regulating axonal polarity.
Appears in Collections:Ph.D Theses (Open)

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